Hairy and Emc negatively regulate morphogenetic furrow progression in the drosophila eye

Nadean L Brown, Carol A. Sattler, Stephen W. Paddock, Sean B. Carroll

Research output: Contribution to journalArticle

120 Citations (Scopus)

Abstract

The initial steps of pattern formation in the developing Drosophila eye involve the coordination of cell cycles, changes in cell shape, and the specification of the R8 photoreceptor cell. These events begin several cell rows ahead of the morphogenetic furrow and are positively regulated by secreted signaling proteins and the proneural HLH transcription factor atonal (ato). Two HLH regulatory proteins that function to suppress neuronal development in other tissues, extra macrochaetae (emc) and hairy (h), are expressed ahead of the morphogenetic furrow. While neither h nor emc is required for photoreceptor cell determination, in emc-h- clones the morphogenetic furrow and differentiated eye field advance up to eight ommatidial rows ahead of adjacent wild-type tissue. This indicates that morphogenetic furrow progression and neuronal differentiation are negatively regulated by a combination of anteriorly expressed HLH regulatory proteins.

Original languageEnglish (US)
Pages (from-to)879-887
Number of pages9
JournalCell
Volume80
Issue number6
DOIs
StatePublished - Mar 24 1995
Externally publishedYes

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Drosophila
Photoreceptor Cells
Tissue
Proteins
Cell Shape
Cell Cycle
Transcription Factors
Clone Cells
Cells
Specifications

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Cell Biology
  • Molecular Biology

Cite this

Hairy and Emc negatively regulate morphogenetic furrow progression in the drosophila eye. / Brown, Nadean L; Sattler, Carol A.; Paddock, Stephen W.; Carroll, Sean B.

In: Cell, Vol. 80, No. 6, 24.03.1995, p. 879-887.

Research output: Contribution to journalArticle

Brown, Nadean L ; Sattler, Carol A. ; Paddock, Stephen W. ; Carroll, Sean B. / Hairy and Emc negatively regulate morphogenetic furrow progression in the drosophila eye. In: Cell. 1995 ; Vol. 80, No. 6. pp. 879-887.
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