Haematological and biochemical changes during anaesthesia with propofol ('Diprivan')

J. W. Sear, Jeffrey Uppington, N. H. Kay

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


The influence of an emulsion formulation of 2,6-diisopropylphenol (propofol) on blood coagulation and fibrinolysis, and on the neuroendocrine responses to surgery has been investigated in 12 patients who received incremental doses of propofol to supplement 67% nitrous oxide in oxygen as anaesthesia for body surface surgery. The effects were compared with those in 10 patients who received Althesin to supplement nitrous oxide in oxygen in a similar manner. When pre-operative values were compared with data obtained after 30 min surgery, no significant effects on coagulation or fibrinolytic indices were found in either group. Both groups, however, showed a significant fall in haemoglobin concentration 30 min after induction of anaesthesia (P<0.05); and a fall in haematocrit value was observed in those patients who received propofol (P<0.05). No changes in total white cell counts or platelet counts were observed. Both groups of patients showed a significant rise in blood glucose 30 min after induction of anaesthesia (P<0.001). After 3 h values were not significantly different from pre-operative levels. The mean plasma cortisol levels fell in both groups 30 min after induction of anaesthesia, but returned to control values by 3 h. The mechanism causing this decrease is not known.

Original languageEnglish (US)
Pages (from-to)165-168
Number of pages4
JournalPostgraduate Medical Journal
Issue numberSUPPL. 3
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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