Habitual diets rich in dark-green vegetables are associated with an increased response to v-3 fatty acid supplementation in americans of african ancestry

Aifric O'Sullivan, Patrice Armstrong, Gertrud U. Schuster, Theresa L. Pedersen, Hooman Allayee, Charles B. Stephensen, John W. Newman

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Although substantial variation exists in individual responses to omega-3 (ω-3) (n-3) fatty acid supplementation, the causes for differences in response are largely unknown. Here we investigated the associations between the efficacy of v-3 fatty acid supplementation and a broad range of nutritional and clinical factors collected during a double-blind, placebocontrolled trial in participants of African ancestry, randomly assigned to receive either 2 g eicosapentaenoic acid (EPA) + 1 g docosahexaenoic acid (n = 41) or corn/soybean oil placebo (n = 42) supplements for 6 wk. Food-frequency questionnaires were administered, and changes in erythrocyte lipids, lipoproteins, and monocyte 5-lipoxygenase- dependent metabolism were measured before and after supplementation. Mixed-mode linear regression modeling identified high (n = 28) and low (n = 13) ω-3 fatty acid response groups on the basis of changes in erythrocyte EPA abundance (P < 0.001). Compliance was equivalent (̃88%), whereas decreases in plasma triglycerides and VLDL particle sizes and reductions in stimulated monocyte leukotriene B4 production were larger in the high-response group. Although total diet quality scores were similar, the low-response group showed lower estimated 2005 Healthy Eating Index subscores for dark-green and orange vegetables and legumes (P = 0.01) and a lower intake of vegetables (P = 0.02), particularly dark-green vegetables (P = 0.002). Because the findings reported here are associative in nature, prospective studies are needed to determine if dietary dark-green vegetables or nutrients contained in these foods can enhance the efficacy of ω-3 fatty acid supplements. This trial was registered at clinicaltrials.gov as NCT00536185.

Original languageEnglish (US)
Pages (from-to)123-131
Number of pages9
JournalJournal of Nutrition
Volume144
Issue number2
DOIs
StatePublished - Feb 1 2014

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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    O'Sullivan, A., Armstrong, P., Schuster, G. U., Pedersen, T. L., Allayee, H., Stephensen, C. B., & Newman, J. W. (2014). Habitual diets rich in dark-green vegetables are associated with an increased response to v-3 fatty acid supplementation in americans of african ancestry. Journal of Nutrition, 144(2), 123-131. https://doi.org/10.3945/jn.113.181875