Abstract
Introduction: Guillain-Barré syndrome is a rare disease representing the most frequent cause of acute flaccid symmetrical weakness of the limbs and areflexia usually reaching its peak within a month. The etiology and pathogenesis remain largely enigmatic and the syndrome results in death or severe disability in 9–17% of cases despite immunotherapy. Areas covered: In terms of etiology, Guillain-Barré syndrome is linked to Campylobacter infection but less than 0.1% of infections result in the syndrome. In terms of pathogenesis, activated macrophages and T cells and serum antibodies against gangliosides are observed but their significance is unclear. Expert commentary: Guillain-Barré syndrome is a heterogeneous condition with numerous subtypes and recent data point towards the role of ganglioside epitopes by immunohistochemical methods. Ultimately, the syndrome results from a permissive genetic background on which environmental factors, including infections, vaccination and the influence of aging, lead to disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1175-1189 |
| Number of pages | 15 |
| Journal | Expert Review of Clinical Immunology |
| Volume | 12 |
| Issue number | 11 |
| DOIs | |
| State | Published - Nov 1 2016 |
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Keywords
- autoimmune neuropathy
- Guillain-Barré
- immune tolerance
- infection and immunity
- Molecular mimicry
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
Cite this
Guillain-Barré syndrome : causes, immunopathogenic mechanisms and treatment. / Jasti, Anil K.; Selmi, Carlo; Sarmiento-Monroy, Juan C.; Vega, Daniel A.; Anaya, Juan Manuel; Gershwin, M. Eric.
In: Expert Review of Clinical Immunology, Vol. 12, No. 11, 01.11.2016, p. 1175-1189.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Guillain-Barré syndrome
T2 - causes, immunopathogenic mechanisms and treatment
AU - Jasti, Anil K.
AU - Selmi, Carlo
AU - Sarmiento-Monroy, Juan C.
AU - Vega, Daniel A.
AU - Anaya, Juan Manuel
AU - Gershwin, M. Eric
PY - 2016/11/1
Y1 - 2016/11/1
N2 - Introduction: Guillain-Barré syndrome is a rare disease representing the most frequent cause of acute flaccid symmetrical weakness of the limbs and areflexia usually reaching its peak within a month. The etiology and pathogenesis remain largely enigmatic and the syndrome results in death or severe disability in 9–17% of cases despite immunotherapy. Areas covered: In terms of etiology, Guillain-Barré syndrome is linked to Campylobacter infection but less than 0.1% of infections result in the syndrome. In terms of pathogenesis, activated macrophages and T cells and serum antibodies against gangliosides are observed but their significance is unclear. Expert commentary: Guillain-Barré syndrome is a heterogeneous condition with numerous subtypes and recent data point towards the role of ganglioside epitopes by immunohistochemical methods. Ultimately, the syndrome results from a permissive genetic background on which environmental factors, including infections, vaccination and the influence of aging, lead to disease.
AB - Introduction: Guillain-Barré syndrome is a rare disease representing the most frequent cause of acute flaccid symmetrical weakness of the limbs and areflexia usually reaching its peak within a month. The etiology and pathogenesis remain largely enigmatic and the syndrome results in death or severe disability in 9–17% of cases despite immunotherapy. Areas covered: In terms of etiology, Guillain-Barré syndrome is linked to Campylobacter infection but less than 0.1% of infections result in the syndrome. In terms of pathogenesis, activated macrophages and T cells and serum antibodies against gangliosides are observed but their significance is unclear. Expert commentary: Guillain-Barré syndrome is a heterogeneous condition with numerous subtypes and recent data point towards the role of ganglioside epitopes by immunohistochemical methods. Ultimately, the syndrome results from a permissive genetic background on which environmental factors, including infections, vaccination and the influence of aging, lead to disease.
KW - autoimmune neuropathy
KW - Guillain-Barré
KW - immune tolerance
KW - infection and immunity
KW - Molecular mimicry
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UR - http://www.scopus.com/inward/citedby.url?scp=84992052404&partnerID=8YFLogxK
U2 - 10.1080/1744666X.2016.1193006
DO - 10.1080/1744666X.2016.1193006
M3 - Review article
C2 - 27292311
AN - SCOPUS:84992052404
VL - 12
SP - 1175
EP - 1189
JO - Expert Review of Clinical Immunology
JF - Expert Review of Clinical Immunology
SN - 1744-666X
IS - 11
ER -