Abstract
The principle of therapy for chronic inflammatory liver diseases is the removal of causal agents. For autoimmune liver diseases, however, total removal of causal agents and immune cells is impossible. Therefore, autoimmune liver diseases are presently treated by suppression of the immune response. Autoimmune hepatitis is characteristically responsive to corticosteroids, often used in combination with azathioprine to obtain a steroidsparing effect. For primary biliary cirrhosis, ursodeoxycholic acid is safe and is the first choice for treatment. Treatment of this autoimmune liver disease should also address various symptoms and complications arising from any associated autoimmune diseases, particularly cholestasis and cirrhosis-related complications. For primary sclerosing cholangitis there are no established immunomodulatory therapies, but medical, endoscopie, and surgical treatments are applicable to this disease. Liver transplantation becomes indicated during the eventual end stages of each of these immune-mediated liver diseases.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 214-226 |
| Number of pages | 13 |
| Journal | Seminars in Liver Disease |
| Volume | 27 |
| Issue number | 2 |
| DOIs | |
| State | Published - May 2007 |
| Externally published | Yes |
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Keywords
- Autoimmune hepatitis
- Guideline
- Overlapping syndrome
- Primary biliary cirrhosis
- Primary sclerosing cholangitis
- Treatment
ASJC Scopus subject areas
- Hepatology
Cite this
Guidelines for therapy of autoimmune liver disease. / Ishibashi, Hiromi; Komori, Atsumasa; Shimoda, Shinji; Gershwin, M. Eric.
In: Seminars in Liver Disease, Vol. 27, No. 2, 05.2007, p. 214-226.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Guidelines for therapy of autoimmune liver disease
AU - Ishibashi, Hiromi
AU - Komori, Atsumasa
AU - Shimoda, Shinji
AU - Gershwin, M. Eric
PY - 2007/5
Y1 - 2007/5
N2 - The principle of therapy for chronic inflammatory liver diseases is the removal of causal agents. For autoimmune liver diseases, however, total removal of causal agents and immune cells is impossible. Therefore, autoimmune liver diseases are presently treated by suppression of the immune response. Autoimmune hepatitis is characteristically responsive to corticosteroids, often used in combination with azathioprine to obtain a steroidsparing effect. For primary biliary cirrhosis, ursodeoxycholic acid is safe and is the first choice for treatment. Treatment of this autoimmune liver disease should also address various symptoms and complications arising from any associated autoimmune diseases, particularly cholestasis and cirrhosis-related complications. For primary sclerosing cholangitis there are no established immunomodulatory therapies, but medical, endoscopie, and surgical treatments are applicable to this disease. Liver transplantation becomes indicated during the eventual end stages of each of these immune-mediated liver diseases.
AB - The principle of therapy for chronic inflammatory liver diseases is the removal of causal agents. For autoimmune liver diseases, however, total removal of causal agents and immune cells is impossible. Therefore, autoimmune liver diseases are presently treated by suppression of the immune response. Autoimmune hepatitis is characteristically responsive to corticosteroids, often used in combination with azathioprine to obtain a steroidsparing effect. For primary biliary cirrhosis, ursodeoxycholic acid is safe and is the first choice for treatment. Treatment of this autoimmune liver disease should also address various symptoms and complications arising from any associated autoimmune diseases, particularly cholestasis and cirrhosis-related complications. For primary sclerosing cholangitis there are no established immunomodulatory therapies, but medical, endoscopie, and surgical treatments are applicable to this disease. Liver transplantation becomes indicated during the eventual end stages of each of these immune-mediated liver diseases.
KW - Autoimmune hepatitis
KW - Guideline
KW - Overlapping syndrome
KW - Primary biliary cirrhosis
KW - Primary sclerosing cholangitis
KW - Treatment
UR - http://www.scopus.com/inward/record.url?scp=34249912673&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34249912673&partnerID=8YFLogxK
U2 - 10.1055/s-2007-979472
DO - 10.1055/s-2007-979472
M3 - Article
C2 - 17520519
AN - SCOPUS:34249912673
VL - 27
SP - 214
EP - 226
JO - Seminars in Liver Disease
JF - Seminars in Liver Disease
SN - 0272-8087
IS - 2
ER -