Guidance molecules in axon pruning and cell death.

Pierre Vanderhaeghen; Hwai-Jong Cheng

doi:10.1101/cshperspect.a001859

Guidance molecules in axon pruning and cell death.

Pierre Vanderhaeghen, Hwai-Jong Cheng

Research output: Contribution to journal › Article

77 Citations (Scopus)

Abstract

Axon pruning and neuronal cell death constitute two major regressive events that enable the establishment of fully mature brain architecture and connectivity. Although the cellular mechanisms for these two events are thought to be distinct, recent evidence has indicated the direct involvement of axon guidance molecules, including semaphorins, netrins, and ephrins, in controlling both processes. Here, we review how axon guidance cues regulate regressive events in paradigmatic models of neural development, from early control of apoptosis of neural progenitors, to later maintenance of neuronal survival and stereotyped pruning of axonal branches. These new findings are also discussed in the context of neural diseases and the potential links between axon pruning and degeneration.

Original language	English (US)
Journal	Cold Spring Harbor perspectives in biology
Volume	2
Issue number	6
DOIs	https://doi.org/10.1101/cshperspect.a001859
State	Published - Jun 1 2010
Externally published	Yes

Fingerprint

Neuronal Plasticity

Cell death

Cell Death

Molecules

Ephrins

Semaphorins

Cues

Maintenance

Apoptosis

Brain

Axons

Axon Guidance

ASJC Scopus subject areas

Medicine(all)

Cite this

Vanderhaeghen, P., & Cheng, H-J. (2010). Guidance molecules in axon pruning and cell death. Cold Spring Harbor perspectives in biology, 2(6). https://doi.org/10.1101/cshperspect.a001859

Guidance molecules in axon pruning and cell death. / Vanderhaeghen, Pierre; Cheng, Hwai-Jong.

In: Cold Spring Harbor perspectives in biology, Vol. 2, No. 6, 01.06.2010.

Research output: Contribution to journal › Article

Vanderhaeghen, P & Cheng, H-J 2010, 'Guidance molecules in axon pruning and cell death.', Cold Spring Harbor perspectives in biology, vol. 2, no. 6. https://doi.org/10.1101/cshperspect.a001859

Vanderhaeghen P, Cheng H-J. Guidance molecules in axon pruning and cell death. Cold Spring Harbor perspectives in biology. 2010 Jun 1;2(6). https://doi.org/10.1101/cshperspect.a001859

Vanderhaeghen, Pierre ; Cheng, Hwai-Jong. / Guidance molecules in axon pruning and cell death. In: Cold Spring Harbor perspectives in biology. 2010 ; Vol. 2, No. 6.

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10.1101/cshperspect.a001859