Guanidinoethane sulfate is neuroprotective towards delayed CA1 neuronal death in gerbils

Hironaka Igarashi, Ingrid Kwee, Tsutomu Nakada

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

The potential neuroprotective effects of guanidinoethane sulfate (GES) on delayed neuronal death of hippocampal CA1 neurons were investigated using a gerbil model of forebrain ischemia. Neuronal densities of CA1 neurons in the saline control group (255.1 ± 11.7 cells/mm) and guanidinoethane sulfate pretreated control group (249.0 ± 9.4 cells/mm) showed no significant differences. By contrast, in animals subjected to ischemia, CA1 neurons of the guanidinoethane sulfate pretreated group showed a significantly higher number of surviving neurons (61.1 ± 55.11 cells/mm) compared to the saline group (17.75 ± 12.73 cells/mm) (p < 0.05, t-test). The study indicated that although partial, guanidinoethane sulfate is neuroprotective towards gerbil hippocampal CA1 neurons against ischemic insult.

Original languageEnglish (US)
Pages (from-to)1201-1206
Number of pages6
JournalLife Sciences
Volume56
Issue number14
DOIs
StatePublished - Feb 24 1995

Keywords

  • CA neurons
  • guanidinoethane sulfate
  • neuroprotection

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Pharmacology

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