Guanidinoethane sulfate is neuroprotective towards delayed CA1 neuronal death in gerbils

Hironaka Igarashi; Ingrid Kwee; Tsutomu Nakada

doi:10.1016/0024-3205(95)00059-F

Guanidinoethane sulfate is neuroprotective towards delayed CA₁ neuronal death in gerbils

Hironaka Igarashi, Ingrid Kwee, Tsutomu Nakada

Neurology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The potential neuroprotective effects of guanidinoethane sulfate (GES) on delayed neuronal death of hippocampal CA₁ neurons were investigated using a gerbil model of forebrain ischemia. Neuronal densities of CA₁ neurons in the saline control group (255.1 ± 11.7 cells/mm) and guanidinoethane sulfate pretreated control group (249.0 ± 9.4 cells/mm) showed no significant differences. By contrast, in animals subjected to ischemia, CA₁ neurons of the guanidinoethane sulfate pretreated group showed a significantly higher number of surviving neurons (61.1 ± 55.11 cells/mm) compared to the saline group (17.75 ± 12.73 cells/mm) (p < 0.05, t-test). The study indicated that although partial, guanidinoethane sulfate is neuroprotective towards gerbil hippocampal CA₁ neurons against ischemic insult.

Original language	English (US)
Pages (from-to)	1201-1206
Number of pages	6
Journal	Life Sciences
Volume	56
Issue number	14
DOIs	https://doi.org/10.1016/0024-3205(95)00059-F
State	Published - Feb 24 1995

Keywords

CA neurons
guanidinoethane sulfate
neuroprotection

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)
Pharmacology

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10.1016/0024-3205(95)00059-F

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title = "Guanidinoethane sulfate is neuroprotective towards delayed CA1 neuronal death in gerbils",

abstract = "The potential neuroprotective effects of guanidinoethane sulfate (GES) on delayed neuronal death of hippocampal CA1 neurons were investigated using a gerbil model of forebrain ischemia. Neuronal densities of CA1 neurons in the saline control group (255.1 ± 11.7 cells/mm) and guanidinoethane sulfate pretreated control group (249.0 ± 9.4 cells/mm) showed no significant differences. By contrast, in animals subjected to ischemia, CA1 neurons of the guanidinoethane sulfate pretreated group showed a significantly higher number of surviving neurons (61.1 ± 55.11 cells/mm) compared to the saline group (17.75 ± 12.73 cells/mm) (p < 0.05, t-test). The study indicated that although partial, guanidinoethane sulfate is neuroprotective towards gerbil hippocampal CA1 neurons against ischemic insult.",

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AU - Igarashi, Hironaka

AU - Kwee, Ingrid

AU - Nakada, Tsutomu

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N2 - The potential neuroprotective effects of guanidinoethane sulfate (GES) on delayed neuronal death of hippocampal CA1 neurons were investigated using a gerbil model of forebrain ischemia. Neuronal densities of CA1 neurons in the saline control group (255.1 ± 11.7 cells/mm) and guanidinoethane sulfate pretreated control group (249.0 ± 9.4 cells/mm) showed no significant differences. By contrast, in animals subjected to ischemia, CA1 neurons of the guanidinoethane sulfate pretreated group showed a significantly higher number of surviving neurons (61.1 ± 55.11 cells/mm) compared to the saline group (17.75 ± 12.73 cells/mm) (p < 0.05, t-test). The study indicated that although partial, guanidinoethane sulfate is neuroprotective towards gerbil hippocampal CA1 neurons against ischemic insult.

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