Abstract
The potential neuroprotective effects of guanidinoethane sulfate (GES) on delayed neuronal death of hippocampal CA1 neurons were investigated using a gerbil model of forebrain ischemia. Neuronal densities of CA1 neurons in the saline control group (255.1 ± 11.7 cells/mm) and guanidinoethane sulfate pretreated control group (249.0 ± 9.4 cells/mm) showed no significant differences. By contrast, in animals subjected to ischemia, CA1 neurons of the guanidinoethane sulfate pretreated group showed a significantly higher number of surviving neurons (61.1 ± 55.11 cells/mm) compared to the saline group (17.75 ± 12.73 cells/mm) (p < 0.05, t-test). The study indicated that although partial, guanidinoethane sulfate is neuroprotective towards gerbil hippocampal CA1 neurons against ischemic insult.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1201-1206 |
| Number of pages | 6 |
| Journal | Life Sciences |
| Volume | 56 |
| Issue number | 14 |
| DOIs | |
| State | Published - Feb 24 1995 |
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Keywords
- CA neurons
- guanidinoethane sulfate
- neuroprotection
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Pharmacology, Toxicology and Pharmaceutics(all)
- Pharmacology
Cite this
Guanidinoethane sulfate is neuroprotective towards delayed CA1 neuronal death in gerbils. / Igarashi, Hironaka; Kwee, Ingrid; Nakada, Tsutomu.
In: Life Sciences, Vol. 56, No. 14, 24.02.1995, p. 1201-1206.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Guanidinoethane sulfate is neuroprotective towards delayed CA1 neuronal death in gerbils
AU - Igarashi, Hironaka
AU - Kwee, Ingrid
AU - Nakada, Tsutomu
PY - 1995/2/24
Y1 - 1995/2/24
N2 - The potential neuroprotective effects of guanidinoethane sulfate (GES) on delayed neuronal death of hippocampal CA1 neurons were investigated using a gerbil model of forebrain ischemia. Neuronal densities of CA1 neurons in the saline control group (255.1 ± 11.7 cells/mm) and guanidinoethane sulfate pretreated control group (249.0 ± 9.4 cells/mm) showed no significant differences. By contrast, in animals subjected to ischemia, CA1 neurons of the guanidinoethane sulfate pretreated group showed a significantly higher number of surviving neurons (61.1 ± 55.11 cells/mm) compared to the saline group (17.75 ± 12.73 cells/mm) (p < 0.05, t-test). The study indicated that although partial, guanidinoethane sulfate is neuroprotective towards gerbil hippocampal CA1 neurons against ischemic insult.
AB - The potential neuroprotective effects of guanidinoethane sulfate (GES) on delayed neuronal death of hippocampal CA1 neurons were investigated using a gerbil model of forebrain ischemia. Neuronal densities of CA1 neurons in the saline control group (255.1 ± 11.7 cells/mm) and guanidinoethane sulfate pretreated control group (249.0 ± 9.4 cells/mm) showed no significant differences. By contrast, in animals subjected to ischemia, CA1 neurons of the guanidinoethane sulfate pretreated group showed a significantly higher number of surviving neurons (61.1 ± 55.11 cells/mm) compared to the saline group (17.75 ± 12.73 cells/mm) (p < 0.05, t-test). The study indicated that although partial, guanidinoethane sulfate is neuroprotective towards gerbil hippocampal CA1 neurons against ischemic insult.
KW - CA neurons
KW - guanidinoethane sulfate
KW - neuroprotection
UR - http://www.scopus.com/inward/record.url?scp=0028900323&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028900323&partnerID=8YFLogxK
U2 - 10.1016/0024-3205(95)00059-F
DO - 10.1016/0024-3205(95)00059-F
M3 - Article
C2 - 7475897
AN - SCOPUS:0028900323
VL - 56
SP - 1201
EP - 1206
JO - Life Sciences
JF - Life Sciences
SN - 0024-3205
IS - 14
ER -