Growth, Nutrition and Cytokine Response of Breast-Fed Infants and Infants Fed Formula with Added Bovine Osteopontin

B. Lönnerdal, Anne Staudt Kvistgaard, Janet M. Peerson, Sharon M. Donovan, Yong mei Peng

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

OBJECTIVES:: Breast milk contains a high concentration of osteopontin (OPN), a protein having multiple functions. In contrast, infant formula is low in OPN. A randomized clinical trial (RCT) was performed to evaluate effects of adding a highly enriched bovine OPN fraction to formula and infants whose mothers had already decided not to breast-feed were recruited. They were fed regular formula (F0) or the same formula with bovine OPN at 65 (F65) or 130 (F130) mg/L (50% and 100% of human milk level, respectively) from 1-6 months of age and were compared to a reference group of breast-fed (BF) infants. METHODS:: Morbidity was recorded daily and 3-day dietary records collected monthly. Anthropometry was assessed monthly and blood samples were taken at 1, 4 and 6 months of age. Hematology and iron status, serum cytokines, plasma amino acids and blood urea nitrogen were analyzed. RESULTS:: Formulas were well tolerated and there were no significant differences in formula intake or growth among the formula-fed groups. The F130 group had significantly lower plasma threonine than the F0 and F65 groups and significantly lower plasma BCAAs than the F0 group and, thus, was closer to BF infants. Plasma TNF-α was higher in formula-fed infants than in BF infants. Among the formula-fed groups, the pro-inflammatory cytokine TNF-α was significantly lower in the F65 and F130 groups than in the F0 group, suggesting that OPN down-regulates inflammatory cytokines and thus affects immune function. CONCLUSIONS:: Addition of OPN to infant formula changes amino acid metabolism and cytokine responses of FF infants and makes them more similar to BF infants. The lower prevalence of pyrexia in the F130 infants than in F0 infants suggests that adding OPN may confer health benefits.

Original languageEnglish (US)
JournalJournal of Pediatric Gastroenterology and Nutrition
DOIs
StateAccepted/In press - Oct 9 2015

Fingerprint

Infant Formula
Osteopontin
Breast
Cytokines
Growth
Human Milk
Diet Records
Amino Acids
Anthropometry
Blood Urea Nitrogen
Insurance Benefits
Hematology
Threonine
Fever
Down-Regulation
Iron
Randomized Controlled Trials
Mothers
Morbidity
Serum

ASJC Scopus subject areas

  • Gastroenterology
  • Pediatrics, Perinatology, and Child Health

Cite this

Growth, Nutrition and Cytokine Response of Breast-Fed Infants and Infants Fed Formula with Added Bovine Osteopontin. / Lönnerdal, B.; Kvistgaard, Anne Staudt; Peerson, Janet M.; Donovan, Sharon M.; Peng, Yong mei.

In: Journal of Pediatric Gastroenterology and Nutrition, 09.10.2015.

Research output: Contribution to journalArticle

Lönnerdal, B. ; Kvistgaard, Anne Staudt ; Peerson, Janet M. ; Donovan, Sharon M. ; Peng, Yong mei. / Growth, Nutrition and Cytokine Response of Breast-Fed Infants and Infants Fed Formula with Added Bovine Osteopontin. In: Journal of Pediatric Gastroenterology and Nutrition. 2015.
@article{22813f1eb8364f59968d27b552d04ba3,
title = "Growth, Nutrition and Cytokine Response of Breast-Fed Infants and Infants Fed Formula with Added Bovine Osteopontin",
abstract = "OBJECTIVES:: Breast milk contains a high concentration of osteopontin (OPN), a protein having multiple functions. In contrast, infant formula is low in OPN. A randomized clinical trial (RCT) was performed to evaluate effects of adding a highly enriched bovine OPN fraction to formula and infants whose mothers had already decided not to breast-feed were recruited. They were fed regular formula (F0) or the same formula with bovine OPN at 65 (F65) or 130 (F130) mg/L (50{\%} and 100{\%} of human milk level, respectively) from 1-6 months of age and were compared to a reference group of breast-fed (BF) infants. METHODS:: Morbidity was recorded daily and 3-day dietary records collected monthly. Anthropometry was assessed monthly and blood samples were taken at 1, 4 and 6 months of age. Hematology and iron status, serum cytokines, plasma amino acids and blood urea nitrogen were analyzed. RESULTS:: Formulas were well tolerated and there were no significant differences in formula intake or growth among the formula-fed groups. The F130 group had significantly lower plasma threonine than the F0 and F65 groups and significantly lower plasma BCAAs than the F0 group and, thus, was closer to BF infants. Plasma TNF-α was higher in formula-fed infants than in BF infants. Among the formula-fed groups, the pro-inflammatory cytokine TNF-α was significantly lower in the F65 and F130 groups than in the F0 group, suggesting that OPN down-regulates inflammatory cytokines and thus affects immune function. CONCLUSIONS:: Addition of OPN to infant formula changes amino acid metabolism and cytokine responses of FF infants and makes them more similar to BF infants. The lower prevalence of pyrexia in the F130 infants than in F0 infants suggests that adding OPN may confer health benefits.",
author = "B. L{\"o}nnerdal and Kvistgaard, {Anne Staudt} and Peerson, {Janet M.} and Donovan, {Sharon M.} and Peng, {Yong mei}",
year = "2015",
month = "10",
day = "9",
doi = "10.1097/MPG.0000000000001005",
language = "English (US)",
journal = "Journal of Pediatric Gastroenterology and Nutrition",
issn = "0277-2116",
publisher = "Lippincott Williams and Wilkins",

}

TY - JOUR

T1 - Growth, Nutrition and Cytokine Response of Breast-Fed Infants and Infants Fed Formula with Added Bovine Osteopontin

AU - Lönnerdal, B.

AU - Kvistgaard, Anne Staudt

AU - Peerson, Janet M.

AU - Donovan, Sharon M.

AU - Peng, Yong mei

PY - 2015/10/9

Y1 - 2015/10/9

N2 - OBJECTIVES:: Breast milk contains a high concentration of osteopontin (OPN), a protein having multiple functions. In contrast, infant formula is low in OPN. A randomized clinical trial (RCT) was performed to evaluate effects of adding a highly enriched bovine OPN fraction to formula and infants whose mothers had already decided not to breast-feed were recruited. They were fed regular formula (F0) or the same formula with bovine OPN at 65 (F65) or 130 (F130) mg/L (50% and 100% of human milk level, respectively) from 1-6 months of age and were compared to a reference group of breast-fed (BF) infants. METHODS:: Morbidity was recorded daily and 3-day dietary records collected monthly. Anthropometry was assessed monthly and blood samples were taken at 1, 4 and 6 months of age. Hematology and iron status, serum cytokines, plasma amino acids and blood urea nitrogen were analyzed. RESULTS:: Formulas were well tolerated and there were no significant differences in formula intake or growth among the formula-fed groups. The F130 group had significantly lower plasma threonine than the F0 and F65 groups and significantly lower plasma BCAAs than the F0 group and, thus, was closer to BF infants. Plasma TNF-α was higher in formula-fed infants than in BF infants. Among the formula-fed groups, the pro-inflammatory cytokine TNF-α was significantly lower in the F65 and F130 groups than in the F0 group, suggesting that OPN down-regulates inflammatory cytokines and thus affects immune function. CONCLUSIONS:: Addition of OPN to infant formula changes amino acid metabolism and cytokine responses of FF infants and makes them more similar to BF infants. The lower prevalence of pyrexia in the F130 infants than in F0 infants suggests that adding OPN may confer health benefits.

AB - OBJECTIVES:: Breast milk contains a high concentration of osteopontin (OPN), a protein having multiple functions. In contrast, infant formula is low in OPN. A randomized clinical trial (RCT) was performed to evaluate effects of adding a highly enriched bovine OPN fraction to formula and infants whose mothers had already decided not to breast-feed were recruited. They were fed regular formula (F0) or the same formula with bovine OPN at 65 (F65) or 130 (F130) mg/L (50% and 100% of human milk level, respectively) from 1-6 months of age and were compared to a reference group of breast-fed (BF) infants. METHODS:: Morbidity was recorded daily and 3-day dietary records collected monthly. Anthropometry was assessed monthly and blood samples were taken at 1, 4 and 6 months of age. Hematology and iron status, serum cytokines, plasma amino acids and blood urea nitrogen were analyzed. RESULTS:: Formulas were well tolerated and there were no significant differences in formula intake or growth among the formula-fed groups. The F130 group had significantly lower plasma threonine than the F0 and F65 groups and significantly lower plasma BCAAs than the F0 group and, thus, was closer to BF infants. Plasma TNF-α was higher in formula-fed infants than in BF infants. Among the formula-fed groups, the pro-inflammatory cytokine TNF-α was significantly lower in the F65 and F130 groups than in the F0 group, suggesting that OPN down-regulates inflammatory cytokines and thus affects immune function. CONCLUSIONS:: Addition of OPN to infant formula changes amino acid metabolism and cytokine responses of FF infants and makes them more similar to BF infants. The lower prevalence of pyrexia in the F130 infants than in F0 infants suggests that adding OPN may confer health benefits.

UR - http://www.scopus.com/inward/record.url?scp=84944338847&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84944338847&partnerID=8YFLogxK

U2 - 10.1097/MPG.0000000000001005

DO - 10.1097/MPG.0000000000001005

M3 - Article

JO - Journal of Pediatric Gastroenterology and Nutrition

JF - Journal of Pediatric Gastroenterology and Nutrition

SN - 0277-2116

ER -