Growth in growth hormone insensitivity

Arlan L. Rosenbloom, Jaime Guevara-Aguirre, Ron G. Rosenfeld, Bradley H Pollock

Research output: Contribution to journalReview article

29 Citations (Scopus)

Abstract

Primary GH insensitivity due to GH receptor deficiency (GHRD) provides a model for studying the discrete effects of severe IGF-I deficiency on growth and body composition. Growth failure in utero is doubtful, but postpartum growth proceeds at rates that result in adult statures 4-12 standard deviations (SDs) below the normal mean. Wide variability in statural effect, even in a genetically homogeneous population, is partly explained by correlation of SD score with biochemical measures of GH effect (IGF-I, IGF-II, and IGFBP-3). Growth and changes in body composition (decreased fat/lean) in patients with GHRD in response to exogenous IGF-I indicate that direct local effects of GH are not necessary for these responses.

Original languageEnglish (US)
Pages (from-to)296-303
Number of pages8
JournalTrends in Endocrinology and Metabolism
Volume5
Issue number7
DOIs
StatePublished - 1994
Externally publishedYes

Fingerprint

Growth Hormone
Insulin-Like Growth Factor I
Growth
Body Composition
Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor II
Postpartum Period
Fats
Population

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Growth in growth hormone insensitivity. / Rosenbloom, Arlan L.; Guevara-Aguirre, Jaime; Rosenfeld, Ron G.; Pollock, Bradley H.

In: Trends in Endocrinology and Metabolism, Vol. 5, No. 7, 1994, p. 296-303.

Research output: Contribution to journalReview article

Rosenbloom, AL, Guevara-Aguirre, J, Rosenfeld, RG & Pollock, BH 1994, 'Growth in growth hormone insensitivity', Trends in Endocrinology and Metabolism, vol. 5, no. 7, pp. 296-303. https://doi.org/10.1016/1043-2760(94)P3205-L
Rosenbloom, Arlan L. ; Guevara-Aguirre, Jaime ; Rosenfeld, Ron G. ; Pollock, Bradley H. / Growth in growth hormone insensitivity. In: Trends in Endocrinology and Metabolism. 1994 ; Vol. 5, No. 7. pp. 296-303.
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