Abstract
To study the relationship of endogenous GHRH to the changes seen in serum GH concentration in neonatal primates, we administered antiserum to GHRH (GHRH-Ab) or GHRH antagonist, (N-Acetyl-Tyr1,D-Arg2) GHRH-(1-29)-NH2, to unanesthetized, fasted rhesus monkeys, 1-31 days of age, via an acutely placed venous catheter. The administration of GHRH-Ab resulted in a significant decrease in serum GH concentration at 1-2 and 7-9 days, but not at 28-31 days of age. The administration of GHRH antagonist resulted in a significant decrease in serum GH concentrations at 1-2 days, but not at 7 or 14 days of age. These results imply that basal serum GH Is more dependent on endogenous GHRH at l-2 days than after 7-28 days of age. This suggests developmental changes in the hypothalamic regulation of GH secretion with advancing age in the neonatal period.
Original language | English (US) |
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Pages (from-to) | 19-28 |
Number of pages | 10 |
Journal | Biology of the Neonate |
Volume | 60 |
Issue number | 1 |
State | Published - 1991 |
Keywords
- antagonist
- antiserum
- growth hormone
- growth hormone-releasing hormone
ASJC Scopus subject areas
- Developmental Biology
- Pediatrics, Perinatology, and Child Health