Growth hormone regulation by growth hormone-releasing hormone in infant rhesus monkeys

M. D. Wheeler, W. W. Wehrenberg, Dennis M Styne

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

To study the relationship of endogenous GHRH to the changes seen in serum GH concentration in neonatal primates, we administered antiserum to GHRH (GHRH-Ab) or GHRH antagonist, (N-Acetyl-Tyr1,D-Arg2) GHRH-(1-29)-NH2, to unanesthetized, fasted rhesus monkeys, 1-31 days of age, via an acutely placed venous catheter. The administration of GHRH-Ab resulted in a significant decrease in serum GH concentration at 1-2 and 7-9 days, but not at 28-31 days of age. The administration of GHRH antagonist resulted in a significant decrease in serum GH concentrations at 1-2 days, but not at 7 or 14 days of age. These results imply that basal serum GH Is more dependent on endogenous GHRH at l-2 days than after 7-28 days of age. This suggests developmental changes in the hypothalamic regulation of GH secretion with advancing age in the neonatal period.

Original languageEnglish (US)
Pages (from-to)19-28
Number of pages10
JournalBiology of the Neonate
Volume60
Issue number1
StatePublished - 1991

Keywords

  • antagonist
  • antiserum
  • growth hormone
  • growth hormone-releasing hormone

ASJC Scopus subject areas

  • Developmental Biology
  • Pediatrics, Perinatology, and Child Health

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