Growth Hormone Induces Low-Density Lipoprotein Clearance but not Bile Acid Synthesis in Humans

Suzanne Lind, Mats Rudling, Sverker Ericsson, Hans Olivecrona, Mats Eriksson, Birgit Borgström, Gösta Eggertsen, Lars Berglund, Bo Angelin

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Objective-Growth hormone (GH) induces hepatic low-density lipoprotein (LDL) receptors and lowers plasma cholesterol. We characterized the influence of GH treatment on plasma LDL clearance in normal humans and investigated the relative role of LDL receptor (LDLR) activity and stimulation of bile acid synthesis in subjects with different LDLR expression. Methods and Results-Plasma clearance of autologous 125I-LDL was measured before and during 3 weeks of treatment with GH (0.1 IU/kg per day) in 9 healthy young males. Plasma LDL cholesterol was reduced by 13% and the fractional catabolic rate of LDL increased by 27%. More marked changes were seen in a patient with hypopituitarism substituted with GH (0.07 IU/kg per day) for 3 months. In a second study, GH dose-dependently reduced LDL cholesterol and increased Lp(a) levels in 3 groups of males: younger and elderly healthy subjects and heterozygous familial hypercholesterolemia (FH). No effect on bile acid synthesis measured by the plasma marker 7α-hydroxy-4-cholesten-3-one was observed. In an LDLR-deficient FH homozygote, LDL cholesterol was not affected by GH. Conclusions-GH treatment reduces plasma LDL cholesterol by inducing LDL clearance. In humans, LDLR expression is a prerequisite for this effect, whereas it is not related to stimulation of bile acid synthesis.

Original languageEnglish (US)
Pages (from-to)349-356
Number of pages8
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume24
Issue number2
DOIs
StatePublished - Feb 2004
Externally publishedYes

Keywords

  • Familial hypercholesterolemia
  • Insulin-like growth factor-I
  • Lipoprotein (a)
  • Low density lipoprotein kinetics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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