Growth hormone

Lisbeth A. Welniak, William J Murphy

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

This chapter discusses growth hormone (GH), also known as somatotropin, which is a molecule with diverse action due in part to the widespread distribution of its receptor. GH is a non-glycoslated polypeptide composed of 191 amino acids and can stimulate the growth and differentiation of muscle, bone and cartilage. In addition to the pituitary gland, GH is produced in many other tissues. This suggests that in addition to its function as a classic endocrine hormone, GH may also function in an autocrine/ paracrine fashion. In addition to direct receptor-mediated activity, GH stimulates the production of insulin-like growth factors (IGFs) that mediate many growth promoting actions of the hormone. The structure and function of growth hormone and its receptors have been intensely studied in the chapter. These studies have contributed greatly to the understanding of receptor activation and signaling.

Original languageEnglish (US)
Title of host publicationThe Cytokine Handbook
PublisherElsevier Inc.
Pages103-113
Number of pages11
ISBN (Print)9780080518794, 9780126896633
DOIs
StatePublished - Jul 7 2003
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

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    Welniak, L. A., & Murphy, W. J. (2003). Growth hormone. In The Cytokine Handbook (pp. 103-113). Elsevier Inc.. https://doi.org/10.1016/B978-012689663-3/50009-0