Growth hormone

Lisbeth A. Welniak; William J Murphy

doi:10.1016/B978-012689663-3/50009-0

Growth hormone

Lisbeth A. Welniak, William J Murphy

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

This chapter discusses growth hormone (GH), also known as somatotropin, which is a molecule with diverse action due in part to the widespread distribution of its receptor. GH is a non-glycoslated polypeptide composed of 191 amino acids and can stimulate the growth and differentiation of muscle, bone and cartilage. In addition to the pituitary gland, GH is produced in many other tissues. This suggests that in addition to its function as a classic endocrine hormone, GH may also function in an autocrine/ paracrine fashion. In addition to direct receptor-mediated activity, GH stimulates the production of insulin-like growth factors (IGFs) that mediate many growth promoting actions of the hormone. The structure and function of growth hormone and its receptors have been intensely studied in the chapter. These studies have contributed greatly to the understanding of receptor activation and signaling.

Original language	English (US)
Title of host publication	The Cytokine Handbook
Publisher	Elsevier Inc.
Pages	103-113
Number of pages	11
ISBN (Print)	9780080518794, 9780126896633
DOIs	https://doi.org/10.1016/B978-012689663-3/50009-0
State	Published - Jul 7 2003
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)
Immunology and Microbiology(all)

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10.1016/B978-012689663-3/50009-0

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abstract = "This chapter discusses growth hormone (GH), also known as somatotropin, which is a molecule with diverse action due in part to the widespread distribution of its receptor. GH is a non-glycoslated polypeptide composed of 191 amino acids and can stimulate the growth and differentiation of muscle, bone and cartilage. In addition to the pituitary gland, GH is produced in many other tissues. This suggests that in addition to its function as a classic endocrine hormone, GH may also function in an autocrine/ paracrine fashion. In addition to direct receptor-mediated activity, GH stimulates the production of insulin-like growth factors (IGFs) that mediate many growth promoting actions of the hormone. The structure and function of growth hormone and its receptors have been intensely studied in the chapter. These studies have contributed greatly to the understanding of receptor activation and signaling.",

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AB - This chapter discusses growth hormone (GH), also known as somatotropin, which is a molecule with diverse action due in part to the widespread distribution of its receptor. GH is a non-glycoslated polypeptide composed of 191 amino acids and can stimulate the growth and differentiation of muscle, bone and cartilage. In addition to the pituitary gland, GH is produced in many other tissues. This suggests that in addition to its function as a classic endocrine hormone, GH may also function in an autocrine/ paracrine fashion. In addition to direct receptor-mediated activity, GH stimulates the production of insulin-like growth factors (IGFs) that mediate many growth promoting actions of the hormone. The structure and function of growth hormone and its receptors have been intensely studied in the chapter. These studies have contributed greatly to the understanding of receptor activation and signaling.

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