Growth factors: Soluble mediators of wound repair and ocular fibrosis

Leonard M Hjelmeland, A. K. Harvey

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


The purpose of the review presented here is the examination of just one facet of the fundamental biochemistry of both proliferative disease of the retina and wound repair. Growth factors play a central role in the wound repair response as soluble mediators of the directed migration and proliferation of connective tissue and endothelial cells. A growing body of evidence also suggests that growth factors play a central role in the formation and growth of cellular membranes in the proliferative retinopathies. Other fields of research into the biochemistry and cell biology of fibrotic diseases, such as idiopathic pulmonary fibrosis and atherosclerosis, have also demonstrated important roles for growth factors. This review first briefly considers the cellular events of wound repair, with a special emphasis on cells that produce growth factors or respond to these same macromolecules. In the second section, the biochemistry of cellular growth factors is examined. The third section then presents findings concerning the role of growth factors in pulmonary fibrosis, to illustrate the impact of growth factor research in the field of fibrosis.

Original languageEnglish (US)
Pages (from-to)87-102
Number of pages16
JournalBirth Defects: Original Article Series
Issue number1
StatePublished - 1988

ASJC Scopus subject areas

  • Developmental Biology
  • Genetics(clinical)


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