Growth factor delivery-based tissue engineering

General approaches and a review of recent developments

Kangwon Lee, Eduardo Silva, David J. Mooney

Research output: Contribution to journalReview article

696 Citations (Scopus)

Abstract

The identification and production of recombinant morphogens and growth factors that play key roles in tissue regeneration have generated much enthusiasm and numerous clinical trials, but the results of many of these trials have been largely disappointing. Interestingly, the trials that have shown benefit all contain a common denominator, the presence of a material carrier, suggesting strongly that spatio-temporal control over the location and bioactivity of factors after introduction into the body is crucial to achieve tangible therapeutic effect. Sophisticated materials systems that regulate the biological presentation of growth factors represent an attractive new generation of therapeutic agents for the treatment of a wide variety of diseases. This review provides an overview of growth factor delivery in tissue engineering. Certain fundamental issues and design strategies relevant to the material carriers that are being actively pursued to address specific technical objectives are discussed. Recent progress highlights the importance of materials science and engineering in growth factor delivery approaches to regenerative medicine.

Original languageEnglish (US)
Pages (from-to)153-170
Number of pages18
JournalJournal of the Royal Society Interface
Volume8
Issue number55
DOIs
StatePublished - Feb 6 2011
Externally publishedYes

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Tissue Engineering
Tissue engineering
Intercellular Signaling Peptides and Proteins
Tissue regeneration
Regenerative Medicine
Therapeutic Uses
Materials science
Bioactivity
Regeneration
Clinical Trials
Therapeutics

Keywords

  • Biomaterials
  • Nanoparticles
  • Regenerative medicine
  • Stimuli-responsive materials
  • Synthetic extracellular matrix

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering

Cite this

Growth factor delivery-based tissue engineering : General approaches and a review of recent developments. / Lee, Kangwon; Silva, Eduardo; Mooney, David J.

In: Journal of the Royal Society Interface, Vol. 8, No. 55, 06.02.2011, p. 153-170.

Research output: Contribution to journalReview article

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