Growth factor delivery-based tissue engineering: General approaches and a review of recent developments

Kangwon Lee, Eduardo Silva, David J. Mooney

Research output: Contribution to journalReview articlepeer-review

956 Scopus citations


The identification and production of recombinant morphogens and growth factors that play key roles in tissue regeneration have generated much enthusiasm and numerous clinical trials, but the results of many of these trials have been largely disappointing. Interestingly, the trials that have shown benefit all contain a common denominator, the presence of a material carrier, suggesting strongly that spatio-temporal control over the location and bioactivity of factors after introduction into the body is crucial to achieve tangible therapeutic effect. Sophisticated materials systems that regulate the biological presentation of growth factors represent an attractive new generation of therapeutic agents for the treatment of a wide variety of diseases. This review provides an overview of growth factor delivery in tissue engineering. Certain fundamental issues and design strategies relevant to the material carriers that are being actively pursued to address specific technical objectives are discussed. Recent progress highlights the importance of materials science and engineering in growth factor delivery approaches to regenerative medicine.

Original languageEnglish (US)
Pages (from-to)153-170
Number of pages18
JournalJournal of the Royal Society Interface
Issue number55
StatePublished - Feb 6 2011
Externally publishedYes


  • Biomaterials
  • Nanoparticles
  • Regenerative medicine
  • Stimuli-responsive materials
  • Synthetic extracellular matrix

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering


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