Grey matter abnormality in progressive multifocal leucoencephalopathy

Christopher Yuki Itoh; Han Sung Lee; Alan Howe Yee

doi:10.1136/practneurol-2020-002852

Grey matter abnormality in progressive multifocal leucoencephalopathy

Christopher Yuki Itoh, Han Sung Lee, Alan Howe Yee

Neurology

Research output: Contribution to journal › Article › peer-review

Abstract

Progressive multifocal leucoencephalopathy (PML) is a demyelinating white matter disease that most often affects immunocompromised people infected by JC virus. The diagnostic gold standard is demonstrable viral DNA or protein from histopathological tissue. However, there are few detailed descriptions of cortical grey matter involvement on neuroimaging. Here we describe the histopathological correlate of cerebral grey matter involvement and radiological accompaniment in a patient with biopsy proven PML.

Original language	English (US)
Journal	Practical Neurology
DOIs	https://doi.org/10.1136/practneurol-2020-002852
State	Accepted/In press - 2021

Keywords

CSF
infectious diseases
neuropathology
neuroradiology
virology

ASJC Scopus subject areas

Clinical Neurology

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keywords = "CSF, infectious diseases, neuropathology, neuroradiology, virology",

author = "Itoh, {Christopher Yuki} and Lee, {Han Sung} and Yee, {Alan Howe}",

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AU - Lee, Han Sung

AU - Yee, Alan Howe

N1 - Publisher Copyright: © Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.

PY - 2021

Y1 - 2021

N2 - Progressive multifocal leucoencephalopathy (PML) is a demyelinating white matter disease that most often affects immunocompromised people infected by JC virus. The diagnostic gold standard is demonstrable viral DNA or protein from histopathological tissue. However, there are few detailed descriptions of cortical grey matter involvement on neuroimaging. Here we describe the histopathological correlate of cerebral grey matter involvement and radiological accompaniment in a patient with biopsy proven PML.

AB - Progressive multifocal leucoencephalopathy (PML) is a demyelinating white matter disease that most often affects immunocompromised people infected by JC virus. The diagnostic gold standard is demonstrable viral DNA or protein from histopathological tissue. However, there are few detailed descriptions of cortical grey matter involvement on neuroimaging. Here we describe the histopathological correlate of cerebral grey matter involvement and radiological accompaniment in a patient with biopsy proven PML.

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KW - infectious diseases

KW - neuropathology

KW - neuroradiology

KW - virology

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Grey matter abnormality in progressive multifocal leucoencephalopathy

Abstract

Keywords

ASJC Scopus subject areas

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