Grey and white matter substrates of action naming

Yu Akinina, O. Dragoy, M. V. Ivanova, E. V. Iskra, O. A. Soloukhina, A. G. Petryshevsky, O. N. Fedinа, A. U. Turken, V. M. Shklovsky, Nina Dronkers

Research output: Contribution to journalArticle

Abstract

Despite a persistent interest in verb processing, data on the neural underpinnings of verb retrieval are fragmentary. The present study is the first to analyze the contributions of both grey and white matter damage affecting verb retrieval through action naming in stroke. We used voxel-based lesion-symptom mapping (VLSM) with an action naming task in 40 left-hemisphere stroke patients. Within the grey matter, we revealed the critical involvement of the left precentral and inferior frontal gyri, insula, and parts of basal ganglia. An overlay of white matter tract probability masks on the VLSM lesion map revealed involvement of left-hemisphere long and short association tracts with terminations in the frontal areas; and several projection tracts. The involvement of these structures is interpreted in the light of existing picture naming models, semantic control processes, and the embodiment cognition framework. Our results stress the importance of both cortico-cortical and cortico-subcortical networks of language processing.

Original languageEnglish (US)
Pages (from-to)249-265
Number of pages17
JournalNeuropsychologia
Volume131
DOIs
StatePublished - Aug 1 2019

Fingerprint

Stroke
Masks
Basal Ganglia
Prefrontal Cortex
Semantics
Cognition
Language
White Matter
Gray Matter

Keywords

  • Aphasia
  • Picture naming
  • Verbs
  • VLSM
  • White-matter tracts

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

Cite this

Akinina, Y., Dragoy, O., Ivanova, M. V., Iskra, E. V., Soloukhina, O. A., Petryshevsky, A. G., ... Dronkers, N. (2019). Grey and white matter substrates of action naming. Neuropsychologia, 131, 249-265. https://doi.org/10.1016/j.neuropsychologia.2019.05.015

Grey and white matter substrates of action naming. / Akinina, Yu; Dragoy, O.; Ivanova, M. V.; Iskra, E. V.; Soloukhina, O. A.; Petryshevsky, A. G.; Fedinа, O. N.; Turken, A. U.; Shklovsky, V. M.; Dronkers, Nina.

In: Neuropsychologia, Vol. 131, 01.08.2019, p. 249-265.

Research output: Contribution to journalArticle

Akinina, Y, Dragoy, O, Ivanova, MV, Iskra, EV, Soloukhina, OA, Petryshevsky, AG, Fedinа, ON, Turken, AU, Shklovsky, VM & Dronkers, N 2019, 'Grey and white matter substrates of action naming', Neuropsychologia, vol. 131, pp. 249-265. https://doi.org/10.1016/j.neuropsychologia.2019.05.015
Akinina Y, Dragoy O, Ivanova MV, Iskra EV, Soloukhina OA, Petryshevsky AG et al. Grey and white matter substrates of action naming. Neuropsychologia. 2019 Aug 1;131:249-265. https://doi.org/10.1016/j.neuropsychologia.2019.05.015
Akinina, Yu ; Dragoy, O. ; Ivanova, M. V. ; Iskra, E. V. ; Soloukhina, O. A. ; Petryshevsky, A. G. ; Fedinа, O. N. ; Turken, A. U. ; Shklovsky, V. M. ; Dronkers, Nina. / Grey and white matter substrates of action naming. In: Neuropsychologia. 2019 ; Vol. 131. pp. 249-265.
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