Greater preexisting interferon γ responses to mycobacterial antigens and lower bacillary load during hiv-associated tuberculosis

Timothy Lahey; Tom Czechura; Scott Crabtree; Robert D. Arbeit; Mecky Matee; C. Robert Horsburgh; Todd Mackenzie; Muhammad Bakari; Kisali Pallangyo; C. Fordham Von Reyn

doi:10.1093/infdis/jit396

Greater preexisting interferon γ responses to mycobacterial antigens and lower bacillary load during hiv-associated tuberculosis

Timothy Lahey, Tom Czechura, Scott Crabtree, Robert D. Arbeit, Mecky Matee, C. Robert Horsburgh, Todd Mackenzie, Muhammad Bakari, Kisali Pallangyo, C. Fordham Von Reyn

Research output: Contribution to journal › Article

2 Scopus citations

Abstract

The role of preexisting interferon (IFN) γ responses in controlling bacillary burden in human immunodeficiency virus (HIV)-associated tuberculosis is not known. Among BCGimmunized HIV-infected adults who developed tuberculosis in a phase III trial of an investigational tuberculosis vaccine, greater baseline IFN-γ responses to early secretory antigenic target 6 and Mycobacterium tuberculosis whole-cell lysate were associated with reduced bacillary burden on sputum smear grade, days to culture positivity on agar, and sputum culture grade during subsequent tuberculosis. This association was most consistent among recipients of the investigational vaccine. When HIV-associated tuberculosis develops, greater preexisting IFN-γ responses to mycobacterial antigens are associated with reduced tuberculosis bacillary burden. ClinicalTrials.gov Identifier. NCT0052195.

Original language	English (US)
Pages (from-to)	1629-1633
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	208
Issue number	10
DOIs	https://doi.org/10.1093/infdis/jit396
State	Published - Nov 15 2013
Externally published	Yes

Keywords

Antigen
HIV
Interferon gamma
Tuberculosis
Vaccine

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

Access to Document

10.1093/infdis/jit396

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Lahey, T., Czechura, T., Crabtree, S., Arbeit, R. D., Matee, M., Horsburgh, C. R., Mackenzie, T., Bakari, M., Pallangyo, K., & Von Reyn, C. F. (2013). Greater preexisting interferon γ responses to mycobacterial antigens and lower bacillary load during hiv-associated tuberculosis. Journal of Infectious Diseases, 208(10), 1629-1633. https://doi.org/10.1093/infdis/jit396

Greater preexisting interferon γ responses to mycobacterial antigens and lower bacillary load during hiv-associated tuberculosis. / Lahey, Timothy; Czechura, Tom; Crabtree, Scott; Arbeit, Robert D.; Matee, Mecky; Horsburgh, C. Robert; Mackenzie, Todd; Bakari, Muhammad; Pallangyo, Kisali; Von Reyn, C. Fordham.

In: Journal of Infectious Diseases, Vol. 208, No. 10, 15.11.2013, p. 1629-1633.

Research output: Contribution to journal › Article

Lahey, Timothy ; Czechura, Tom ; Crabtree, Scott ; Arbeit, Robert D. ; Matee, Mecky ; Horsburgh, C. Robert ; Mackenzie, Todd ; Bakari, Muhammad ; Pallangyo, Kisali ; Von Reyn, C. Fordham. / Greater preexisting interferon γ responses to mycobacterial antigens and lower bacillary load during hiv-associated tuberculosis. In: Journal of Infectious Diseases. 2013 ; Vol. 208, No. 10. pp. 1629-1633.

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