Greater preexisting interferon γ responses to mycobacterial antigens and lower bacillary load during hiv-associated tuberculosis

Timothy Lahey; Tom Czechura; Scott Crabtree; Robert D. Arbeit; Mecky Matee; C. Robert Horsburgh; Todd Mackenzie; Muhammad Bakari; Kisali Pallangyo; C. Fordham Von Reyn

doi:10.1093/infdis/jit396

Greater preexisting interferon γ responses to mycobacterial antigens and lower bacillary load during hiv-associated tuberculosis

Timothy Lahey, Tom Czechura, Scott Crabtree, Robert D. Arbeit, Mecky Matee, C. Robert Horsburgh, Todd Mackenzie, Muhammad Bakari, Kisali Pallangyo, C. Fordham Von Reyn

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The role of preexisting interferon (IFN) γ responses in controlling bacillary burden in human immunodeficiency virus (HIV)-associated tuberculosis is not known. Among BCGimmunized HIV-infected adults who developed tuberculosis in a phase III trial of an investigational tuberculosis vaccine, greater baseline IFN-γ responses to early secretory antigenic target 6 and Mycobacterium tuberculosis whole-cell lysate were associated with reduced bacillary burden on sputum smear grade, days to culture positivity on agar, and sputum culture grade during subsequent tuberculosis. This association was most consistent among recipients of the investigational vaccine. When HIV-associated tuberculosis develops, greater preexisting IFN-γ responses to mycobacterial antigens are associated with reduced tuberculosis bacillary burden. ClinicalTrials.gov Identifier. NCT0052195.

Original language	English (US)
Pages (from-to)	1629-1633
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	208
Issue number	10
DOIs	https://doi.org/10.1093/infdis/jit396
State	Published - Nov 15 2013
Externally published	Yes

Keywords

Antigen
HIV
Interferon gamma
Tuberculosis
Vaccine

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

Access to Document

10.1093/infdis/jit396

Fingerprint Dive into the research topics of 'Greater preexisting interferon γ responses to mycobacterial antigens and lower bacillary load during hiv-associated tuberculosis'. Together they form a unique fingerprint.

Cite this

Lahey, T., Czechura, T., Crabtree, S., Arbeit, R. D., Matee, M., Horsburgh, C. R., Mackenzie, T., Bakari, M., Pallangyo, K., & Von Reyn, C. F. (2013). Greater preexisting interferon γ responses to mycobacterial antigens and lower bacillary load during hiv-associated tuberculosis. Journal of Infectious Diseases, 208(10), 1629-1633. https://doi.org/10.1093/infdis/jit396

Greater preexisting interferon γ responses to mycobacterial antigens and lower bacillary load during hiv-associated tuberculosis. / Lahey, Timothy; Czechura, Tom; Crabtree, Scott; Arbeit, Robert D.; Matee, Mecky; Horsburgh, C. Robert; Mackenzie, Todd; Bakari, Muhammad; Pallangyo, Kisali; Von Reyn, C. Fordham.

In: Journal of Infectious Diseases, Vol. 208, No. 10, 15.11.2013, p. 1629-1633.

Research output: Contribution to journal › Article › peer-review

Lahey, Timothy ; Czechura, Tom ; Crabtree, Scott ; Arbeit, Robert D. ; Matee, Mecky ; Horsburgh, C. Robert ; Mackenzie, Todd ; Bakari, Muhammad ; Pallangyo, Kisali ; Von Reyn, C. Fordham. / Greater preexisting interferon γ responses to mycobacterial antigens and lower bacillary load during hiv-associated tuberculosis. In: Journal of Infectious Diseases. 2013 ; Vol. 208, No. 10. pp. 1629-1633.

@article{9219f7fbafd3409d97b9ee248b85786b,

title = "Greater preexisting interferon γ responses to mycobacterial antigens and lower bacillary load during hiv-associated tuberculosis",

abstract = "The role of preexisting interferon (IFN) γ responses in controlling bacillary burden in human immunodeficiency virus (HIV)-associated tuberculosis is not known. Among BCGimmunized HIV-infected adults who developed tuberculosis in a phase III trial of an investigational tuberculosis vaccine, greater baseline IFN-γ responses to early secretory antigenic target 6 and Mycobacterium tuberculosis whole-cell lysate were associated with reduced bacillary burden on sputum smear grade, days to culture positivity on agar, and sputum culture grade during subsequent tuberculosis. This association was most consistent among recipients of the investigational vaccine. When HIV-associated tuberculosis develops, greater preexisting IFN-γ responses to mycobacterial antigens are associated with reduced tuberculosis bacillary burden. ClinicalTrials.gov Identifier. NCT0052195.",

keywords = "Antigen, HIV, Interferon gamma, Tuberculosis, Vaccine",

author = "Timothy Lahey and Tom Czechura and Scott Crabtree and Arbeit, {Robert D.} and Mecky Matee and Horsburgh, {C. Robert} and Todd Mackenzie and Muhammad Bakari and Kisali Pallangyo and {Von Reyn}, {C. Fordham}",

year = "2013",

month = nov,

day = "15",

doi = "10.1093/infdis/jit396",

language = "English (US)",

volume = "208",

pages = "1629--1633",

journal = "Journal of Infectious Diseases",

issn = "0022-1899",

publisher = "Oxford University Press",

number = "10",

}

TY - JOUR

T1 - Greater preexisting interferon γ responses to mycobacterial antigens and lower bacillary load during hiv-associated tuberculosis

AU - Lahey, Timothy

AU - Czechura, Tom

AU - Crabtree, Scott

AU - Arbeit, Robert D.

AU - Matee, Mecky

AU - Horsburgh, C. Robert

AU - Mackenzie, Todd

AU - Bakari, Muhammad

AU - Pallangyo, Kisali

AU - Von Reyn, C. Fordham

PY - 2013/11/15

Y1 - 2013/11/15

N2 - The role of preexisting interferon (IFN) γ responses in controlling bacillary burden in human immunodeficiency virus (HIV)-associated tuberculosis is not known. Among BCGimmunized HIV-infected adults who developed tuberculosis in a phase III trial of an investigational tuberculosis vaccine, greater baseline IFN-γ responses to early secretory antigenic target 6 and Mycobacterium tuberculosis whole-cell lysate were associated with reduced bacillary burden on sputum smear grade, days to culture positivity on agar, and sputum culture grade during subsequent tuberculosis. This association was most consistent among recipients of the investigational vaccine. When HIV-associated tuberculosis develops, greater preexisting IFN-γ responses to mycobacterial antigens are associated with reduced tuberculosis bacillary burden. ClinicalTrials.gov Identifier. NCT0052195.

AB - The role of preexisting interferon (IFN) γ responses in controlling bacillary burden in human immunodeficiency virus (HIV)-associated tuberculosis is not known. Among BCGimmunized HIV-infected adults who developed tuberculosis in a phase III trial of an investigational tuberculosis vaccine, greater baseline IFN-γ responses to early secretory antigenic target 6 and Mycobacterium tuberculosis whole-cell lysate were associated with reduced bacillary burden on sputum smear grade, days to culture positivity on agar, and sputum culture grade during subsequent tuberculosis. This association was most consistent among recipients of the investigational vaccine. When HIV-associated tuberculosis develops, greater preexisting IFN-γ responses to mycobacterial antigens are associated with reduced tuberculosis bacillary burden. ClinicalTrials.gov Identifier. NCT0052195.

KW - Antigen

KW - HIV

KW - Interferon gamma

KW - Tuberculosis

KW - Vaccine

UR - http://www.scopus.com/inward/record.url?scp=84888633733&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84888633733&partnerID=8YFLogxK

U2 - 10.1093/infdis/jit396

DO - 10.1093/infdis/jit396

M3 - Article

C2 - 23908490

AN - SCOPUS:84888633733

VL - 208

SP - 1629

EP - 1633

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 10

ER -

Greater preexisting interferon γ responses to mycobacterial antigens and lower bacillary load during hiv-associated tuberculosis

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this