Greater preexisting interferon γ responses to mycobacterial antigens and lower bacillary load during hiv-associated tuberculosis

Timothy Lahey, Tom Czechura, Scott Crabtree, Robert D. Arbeit, Mecky Matee, C. Robert Horsburgh, Todd Mackenzie, Muhammad Bakari, Kisali Pallangyo, C. Fordham Von Reyn

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The role of preexisting interferon (IFN) γ responses in controlling bacillary burden in human immunodeficiency virus (HIV)-associated tuberculosis is not known. Among BCGimmunized HIV-infected adults who developed tuberculosis in a phase III trial of an investigational tuberculosis vaccine, greater baseline IFN-γ responses to early secretory antigenic target 6 and Mycobacterium tuberculosis whole-cell lysate were associated with reduced bacillary burden on sputum smear grade, days to culture positivity on agar, and sputum culture grade during subsequent tuberculosis. This association was most consistent among recipients of the investigational vaccine. When HIV-associated tuberculosis develops, greater preexisting IFN-γ responses to mycobacterial antigens are associated with reduced tuberculosis bacillary burden. ClinicalTrials.gov Identifier. NCT0052195.

Original languageEnglish (US)
Pages (from-to)1629-1633
Number of pages5
JournalJournal of Infectious Diseases
Volume208
Issue number10
DOIs
StatePublished - Nov 15 2013
Externally publishedYes

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Keywords

  • Antigen
  • HIV
  • Interferon gamma
  • Tuberculosis
  • Vaccine

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Lahey, T., Czechura, T., Crabtree, S., Arbeit, R. D., Matee, M., Horsburgh, C. R., Mackenzie, T., Bakari, M., Pallangyo, K., & Von Reyn, C. F. (2013). Greater preexisting interferon γ responses to mycobacterial antigens and lower bacillary load during hiv-associated tuberculosis. Journal of Infectious Diseases, 208(10), 1629-1633. https://doi.org/10.1093/infdis/jit396