Graph theory network function in parkinson's disease assessed with electroencephalography

Rene L. Utianski, John N. Caviness, Elisabeth C.W. van Straaten, Thomas G. Beach, Brittany Dugger, Holly A. Shill, Erika D. Driver-Dunckley, Marwan N. Sabbagh, Shyamal Mehta, Charles H. Adler, Joseph G. Hentz

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Objectives: To determine what differences exist in graph theory network measures derived from electroencephalography (EEG), between Parkinson's disease (PD) patients who are cognitively normal (PD-CN) and matched healthy controls; and between PD-CN and PD dementia (PD-D). Methods: EEG recordings were analyzed via graph theory network analysis to quantify changes in global efficiency and local integration. This included minimal spanning tree analysis. T-tests and correlations were used to assess differences between groups and assess the relationship with cognitive performance. Results: Network measures showed increased local integration across all frequency bands between control and PD-CN; in contrast, decreased local integration occurred in PD-D when compared to PD-CN in the alpha1 frequency band. Differences found in PD-MCI mirrored PD-D. Correlations were found between network measures and assessments of global cognitive performance in PD. Conclusions: Our results reveal distinct patterns of band and network measure type alteration and breakdown for PD, as well as with cognitive decline in PD. Significance: These patterns suggest specific ways that interaction between cortical areas becomes abnormal and contributes to PD symptoms at various stages. Graph theory analysis by EEG suggests that network alteration and breakdown are robust attributes of PD cortical dysfunction pathophysiology.

Original languageEnglish (US)
Pages (from-to)2228-2236
Number of pages9
JournalClinical Neurophysiology
Volume127
Issue number5
DOIs
StatePublished - May 1 2016

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Parkinson Disease
Electroencephalography
Dementia

Keywords

  • Biomarker
  • Dementia
  • EEG
  • Network
  • Parkinson's disease
  • Pathology
  • Synucleinopathy

ASJC Scopus subject areas

  • Sensory Systems
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

Cite this

Utianski, R. L., Caviness, J. N., van Straaten, E. C. W., Beach, T. G., Dugger, B., Shill, H. A., ... Hentz, J. G. (2016). Graph theory network function in parkinson's disease assessed with electroencephalography. Clinical Neurophysiology, 127(5), 2228-2236. https://doi.org/10.1016/j.clinph.2016.02.017

Graph theory network function in parkinson's disease assessed with electroencephalography. / Utianski, Rene L.; Caviness, John N.; van Straaten, Elisabeth C.W.; Beach, Thomas G.; Dugger, Brittany; Shill, Holly A.; Driver-Dunckley, Erika D.; Sabbagh, Marwan N.; Mehta, Shyamal; Adler, Charles H.; Hentz, Joseph G.

In: Clinical Neurophysiology, Vol. 127, No. 5, 01.05.2016, p. 2228-2236.

Research output: Contribution to journalArticle

Utianski, RL, Caviness, JN, van Straaten, ECW, Beach, TG, Dugger, B, Shill, HA, Driver-Dunckley, ED, Sabbagh, MN, Mehta, S, Adler, CH & Hentz, JG 2016, 'Graph theory network function in parkinson's disease assessed with electroencephalography', Clinical Neurophysiology, vol. 127, no. 5, pp. 2228-2236. https://doi.org/10.1016/j.clinph.2016.02.017
Utianski, Rene L. ; Caviness, John N. ; van Straaten, Elisabeth C.W. ; Beach, Thomas G. ; Dugger, Brittany ; Shill, Holly A. ; Driver-Dunckley, Erika D. ; Sabbagh, Marwan N. ; Mehta, Shyamal ; Adler, Charles H. ; Hentz, Joseph G. / Graph theory network function in parkinson's disease assessed with electroencephalography. In: Clinical Neurophysiology. 2016 ; Vol. 127, No. 5. pp. 2228-2236.
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