Abstract
The GCT is the most common ovarian tumor in mares. A clinical diagnosis can be made based on the presence of a unilaterally enlarged ovary and a small inactive contralateral ovary. Endocrine testing may be beneficial to confirm a diagnosis. Plasma inhibin and testosterone concentrations are elevated in approximately 90% and 50% to 60%, respectively, of mares with GCTs. Testosterone is elevated if the tumor has a significant thecal cell component, and affected mares exhibit stallion-like behavior. Hormones produced by the tumor result in suppression of pituitary FSH secretion and inactivity in the opposite ovary. Surgical removal of the tumor eliminates the adverse effect on pituitary function and results in resumption of follicular development and ovulation over time.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 799-817 |
| Number of pages | 19 |
| Journal | Veterinary Clinics of North America - Equine Practice |
| Volume | 22 |
| Issue number | 3 |
| DOIs | |
| State | Published - Dec 1 2006 |
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ASJC Scopus subject areas
- Equine
Cite this
Granulosa Cell Tumors of the Equine Ovary. / McCue, Patrick M.; Roser, Janet F.; Munro, Coralie J.; Liu, Irwin; Lasley, Bill L.
In: Veterinary Clinics of North America - Equine Practice, Vol. 22, No. 3, 01.12.2006, p. 799-817.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Granulosa Cell Tumors of the Equine Ovary
AU - McCue, Patrick M.
AU - Roser, Janet F.
AU - Munro, Coralie J.
AU - Liu, Irwin
AU - Lasley, Bill L.
PY - 2006/12/1
Y1 - 2006/12/1
N2 - The GCT is the most common ovarian tumor in mares. A clinical diagnosis can be made based on the presence of a unilaterally enlarged ovary and a small inactive contralateral ovary. Endocrine testing may be beneficial to confirm a diagnosis. Plasma inhibin and testosterone concentrations are elevated in approximately 90% and 50% to 60%, respectively, of mares with GCTs. Testosterone is elevated if the tumor has a significant thecal cell component, and affected mares exhibit stallion-like behavior. Hormones produced by the tumor result in suppression of pituitary FSH secretion and inactivity in the opposite ovary. Surgical removal of the tumor eliminates the adverse effect on pituitary function and results in resumption of follicular development and ovulation over time.
AB - The GCT is the most common ovarian tumor in mares. A clinical diagnosis can be made based on the presence of a unilaterally enlarged ovary and a small inactive contralateral ovary. Endocrine testing may be beneficial to confirm a diagnosis. Plasma inhibin and testosterone concentrations are elevated in approximately 90% and 50% to 60%, respectively, of mares with GCTs. Testosterone is elevated if the tumor has a significant thecal cell component, and affected mares exhibit stallion-like behavior. Hormones produced by the tumor result in suppression of pituitary FSH secretion and inactivity in the opposite ovary. Surgical removal of the tumor eliminates the adverse effect on pituitary function and results in resumption of follicular development and ovulation over time.
UR - http://www.scopus.com/inward/record.url?scp=33751206830&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33751206830&partnerID=8YFLogxK
U2 - 10.1016/j.cveq.2006.08.008
DO - 10.1016/j.cveq.2006.08.008
M3 - Review article
C2 - 17129804
AN - SCOPUS:33751206830
VL - 22
SP - 799
EP - 817
JO - Veterinary Clinics of North America. Equine Practice
JF - Veterinary Clinics of North America. Equine Practice
SN - 0749-0739
IS - 3
ER -