Granulosa Cell Tumors of the Equine Ovary

Patrick M. McCue; Janet F. Roser; Coralie J. Munro; Irwin Liu; Bill L. Lasley

doi:10.1016/j.cveq.2006.08.008

Granulosa Cell Tumors of the Equine Ovary

Patrick M. McCue, Janet F. Roser, Coralie J. Munro, Irwin Liu, Bill L. Lasley

School of Veterinary Medicine

Research output: Contribution to journal › Review article

57 Scopus citations

Abstract

The GCT is the most common ovarian tumor in mares. A clinical diagnosis can be made based on the presence of a unilaterally enlarged ovary and a small inactive contralateral ovary. Endocrine testing may be beneficial to confirm a diagnosis. Plasma inhibin and testosterone concentrations are elevated in approximately 90% and 50% to 60%, respectively, of mares with GCTs. Testosterone is elevated if the tumor has a significant thecal cell component, and affected mares exhibit stallion-like behavior. Hormones produced by the tumor result in suppression of pituitary FSH secretion and inactivity in the opposite ovary. Surgical removal of the tumor eliminates the adverse effect on pituitary function and results in resumption of follicular development and ovulation over time.

Original language	English (US)
Pages (from-to)	799-817
Number of pages	19
Journal	Veterinary Clinics of North America - Equine Practice
Volume	22
Issue number	3
DOIs	https://doi.org/10.1016/j.cveq.2006.08.008
State	Published - Dec 1 2006

ASJC Scopus subject areas

Equine

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McCue, P. M., Roser, J. F., Munro, C. J., Liu, I., & Lasley, B. L. (2006). Granulosa Cell Tumors of the Equine Ovary. Veterinary Clinics of North America - Equine Practice, 22(3), 799-817. https://doi.org/10.1016/j.cveq.2006.08.008

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