Granulosa Cell Tumors in two cycling mares

P. M. McCue,, M. M. LeBlanc,, G. Y. Akita,, John Pascoe, D. M. Witherspoon,, G. H. Stabenfeldt,

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


The granulosa-theca cell tumor (GTCT) is the most common ovarian tumor of the horse.4,7 Mares with a GTCT may exhibit continuous or intermittent estrus, stallion-like behavior or may remain anestrus.4 The hormone secretory profile of the tumor dictates the behavior expressed, with mares having elevated plasma testosterone concentrations (>100 pg/ml) exhibiting stallion-like behavior.7 The ultrasonic appearance of the affected ovary ranges from a homogenous echogenic mass to a multicystic or 'honeycomb' pattern.1 The contralateral ovary is usually small and inactive,4,7 although one mare with a functional contralateral ovary was recently described.2 Mares with an inactive contralateral ovary resume normal cyclic ovarian activity 2-16 months after removal of the affected ovary4 Clinical diagnosis of a GTCT is based on history, behavior, presence of a unilaterally enlarged ovary with an inactive contralateral ovary, and in some cases, elevated plasma testosterone concentrations. This report documents the presence of a granulosa cell tumor in two mares which exhibited normal follicular development, ovulation and luteal function in the contralateral ovary.

Original languageEnglish (US)
Pages (from-to)281-282
Number of pages2
JournalJournal of Equine Veterinary Science
Issue number5
StatePublished - Jan 1 1991

ASJC Scopus subject areas

  • Equine


Dive into the research topics of 'Granulosa Cell Tumors in two cycling mares'. Together they form a unique fingerprint.

Cite this