Granulocyte colony-stimulating factor demonstrates antitumor activity in melanoma model in mice

J. Gołab, R. Zagoźdzon, T. Stokłosa, A. Kaca, A. Dabrowska, Adam Giermasz, W. Feleszko, M. Jakóbisiak

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Granulocyte colony-stimulating factor (G-CSF) was found to exert antitumor activity against murine MmB 16 melanoma when administered intratumorally. However, subcutaneous administration of this cytokine at a site distant from the growing tumor did not show any antitumor effects. G- CSF did not influence the proliferative activity of MmB 16 in vitro. Intraperitoneal administration of G-CSF resulted in decreased secretion of nitric oxide (NO) by peritoneal macrophages and their decreased tumoricidal activity against MmB 16.

Original languageEnglish (US)
Pages (from-to)35-39
Number of pages5
JournalNeoplasma
Volume45
Issue number1
StatePublished - 1998
Externally publishedYes

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Granulocyte Colony-Stimulating Factor
Melanoma
Peritoneal Macrophages
Nitric Oxide
Cytokines
Neoplasms

Keywords

  • Granulocyte colony-stimulating factor
  • Macrophages
  • Melanoma MmB16
  • Nitric oxide

ASJC Scopus subject areas

  • Cancer Research

Cite this

Gołab, J., Zagoźdzon, R., Stokłosa, T., Kaca, A., Dabrowska, A., Giermasz, A., ... Jakóbisiak, M. (1998). Granulocyte colony-stimulating factor demonstrates antitumor activity in melanoma model in mice. Neoplasma, 45(1), 35-39.

Granulocyte colony-stimulating factor demonstrates antitumor activity in melanoma model in mice. / Gołab, J.; Zagoźdzon, R.; Stokłosa, T.; Kaca, A.; Dabrowska, A.; Giermasz, Adam; Feleszko, W.; Jakóbisiak, M.

In: Neoplasma, Vol. 45, No. 1, 1998, p. 35-39.

Research output: Contribution to journalArticle

Gołab, J, Zagoźdzon, R, Stokłosa, T, Kaca, A, Dabrowska, A, Giermasz, A, Feleszko, W & Jakóbisiak, M 1998, 'Granulocyte colony-stimulating factor demonstrates antitumor activity in melanoma model in mice', Neoplasma, vol. 45, no. 1, pp. 35-39.
Gołab J, Zagoźdzon R, Stokłosa T, Kaca A, Dabrowska A, Giermasz A et al. Granulocyte colony-stimulating factor demonstrates antitumor activity in melanoma model in mice. Neoplasma. 1998;45(1):35-39.
Gołab, J. ; Zagoźdzon, R. ; Stokłosa, T. ; Kaca, A. ; Dabrowska, A. ; Giermasz, Adam ; Feleszko, W. ; Jakóbisiak, M. / Granulocyte colony-stimulating factor demonstrates antitumor activity in melanoma model in mice. In: Neoplasma. 1998 ; Vol. 45, No. 1. pp. 35-39.
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