Abstract
Granulocyte colony-stimulating factor (G-CSF) was found to exert antitumor activity against murine MmB 16 melanoma when administered intratumorally. However, subcutaneous administration of this cytokine at a site distant from the growing tumor did not show any antitumor effects. G- CSF did not influence the proliferative activity of MmB 16 in vitro. Intraperitoneal administration of G-CSF resulted in decreased secretion of nitric oxide (NO) by peritoneal macrophages and their decreased tumoricidal activity against MmB 16.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 35-39 |
| Number of pages | 5 |
| Journal | Neoplasma |
| Volume | 45 |
| Issue number | 1 |
| State | Published - 1998 |
| Externally published | Yes |
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Keywords
- Granulocyte colony-stimulating factor
- Macrophages
- Melanoma MmB16
- Nitric oxide
ASJC Scopus subject areas
- Cancer Research
Cite this
Granulocyte colony-stimulating factor demonstrates antitumor activity in melanoma model in mice. / Gołab, J.; Zagoźdzon, R.; Stokłosa, T.; Kaca, A.; Dabrowska, A.; Giermasz, Adam; Feleszko, W.; Jakóbisiak, M.
In: Neoplasma, Vol. 45, No. 1, 1998, p. 35-39.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Granulocyte colony-stimulating factor demonstrates antitumor activity in melanoma model in mice
AU - Gołab, J.
AU - Zagoźdzon, R.
AU - Stokłosa, T.
AU - Kaca, A.
AU - Dabrowska, A.
AU - Giermasz, Adam
AU - Feleszko, W.
AU - Jakóbisiak, M.
PY - 1998
Y1 - 1998
N2 - Granulocyte colony-stimulating factor (G-CSF) was found to exert antitumor activity against murine MmB 16 melanoma when administered intratumorally. However, subcutaneous administration of this cytokine at a site distant from the growing tumor did not show any antitumor effects. G- CSF did not influence the proliferative activity of MmB 16 in vitro. Intraperitoneal administration of G-CSF resulted in decreased secretion of nitric oxide (NO) by peritoneal macrophages and their decreased tumoricidal activity against MmB 16.
AB - Granulocyte colony-stimulating factor (G-CSF) was found to exert antitumor activity against murine MmB 16 melanoma when administered intratumorally. However, subcutaneous administration of this cytokine at a site distant from the growing tumor did not show any antitumor effects. G- CSF did not influence the proliferative activity of MmB 16 in vitro. Intraperitoneal administration of G-CSF resulted in decreased secretion of nitric oxide (NO) by peritoneal macrophages and their decreased tumoricidal activity against MmB 16.
KW - Granulocyte colony-stimulating factor
KW - Macrophages
KW - Melanoma MmB16
KW - Nitric oxide
UR - http://www.scopus.com/inward/record.url?scp=0031972130&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031972130&partnerID=8YFLogxK
M3 - Article
C2 - 9605000
AN - SCOPUS:0031972130
VL - 45
SP - 35
EP - 39
JO - Neoplasma
JF - Neoplasma
SN - 0028-2685
IS - 1
ER -