Abstract
Granulocyte colony-stimulating factor (G-CSF) was found to exert antitumor activity against murine MmB 16 melanoma when administered intratumorally. However, subcutaneous administration of this cytokine at a site distant from the growing tumor did not show any antitumor effects. G- CSF did not influence the proliferative activity of MmB 16 in vitro. Intraperitoneal administration of G-CSF resulted in decreased secretion of nitric oxide (NO) by peritoneal macrophages and their decreased tumoricidal activity against MmB 16.
Original language | English (US) |
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Pages (from-to) | 35-39 |
Number of pages | 5 |
Journal | Neoplasma |
Volume | 45 |
Issue number | 1 |
State | Published - 1998 |
Externally published | Yes |
Keywords
- Granulocyte colony-stimulating factor
- Macrophages
- Melanoma MmB16
- Nitric oxide
ASJC Scopus subject areas
- Cancer Research