Abstract
Granulocyte colony-stimulating factor (G-CSF) was found to exert antitumor activity against murine MmB 16 melanoma when administered intratumorally. However, subcutaneous administration of this cytokine at a site distant from the growing tumor did not show any antitumor effects. G- CSF did not influence the proliferative activity of MmB 16 in vitro. Intraperitoneal administration of G-CSF resulted in decreased secretion of nitric oxide (NO) by peritoneal macrophages and their decreased tumoricidal activity against MmB 16.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 35-39 |
| Number of pages | 5 |
| Journal | Neoplasma |
| Volume | 45 |
| Issue number | 1 |
| State | Published - 1998 |
| Externally published | Yes |
Keywords
- Granulocyte colony-stimulating factor
- Macrophages
- Melanoma MmB16
- Nitric oxide
ASJC Scopus subject areas
- Cancer Research
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Cite this
Gołab, J., Zagoźdzon, R., Stokłosa, T., Kaca, A., Dabrowska, A., Giermasz, A., Feleszko, W., & Jakóbisiak, M. (1998). Granulocyte colony-stimulating factor demonstrates antitumor activity in melanoma model in mice. Neoplasma, 45(1), 35-39.