Granulocyte colony-stimulating factor demonstrates antitumor activity in melanoma model in mice

J. Gołab, R. Zagoźdzon, T. Stokłosa, A. Kaca, A. Dabrowska, Adam Giermasz, W. Feleszko, M. Jakóbisiak

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Granulocyte colony-stimulating factor (G-CSF) was found to exert antitumor activity against murine MmB 16 melanoma when administered intratumorally. However, subcutaneous administration of this cytokine at a site distant from the growing tumor did not show any antitumor effects. G- CSF did not influence the proliferative activity of MmB 16 in vitro. Intraperitoneal administration of G-CSF resulted in decreased secretion of nitric oxide (NO) by peritoneal macrophages and their decreased tumoricidal activity against MmB 16.

Original languageEnglish (US)
Pages (from-to)35-39
Number of pages5
JournalNeoplasma
Volume45
Issue number1
StatePublished - 1998
Externally publishedYes

Keywords

  • Granulocyte colony-stimulating factor
  • Macrophages
  • Melanoma MmB16
  • Nitric oxide

ASJC Scopus subject areas

  • Cancer Research

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