Granulocyte colony-stimulating factor demonstrates antitumor activity in melanoma model in mice

J. Gołab; R. Zagoźdzon; T. Stokłosa; A. Kaca; A. Dabrowska; Adam Giermasz; W. Feleszko; M. Jakóbisiak

Granulocyte colony-stimulating factor demonstrates antitumor activity in melanoma model in mice

J. Gołab, R. Zagoźdzon, T. Stokłosa, A. Kaca, A. Dabrowska, Adam Giermasz, W. Feleszko, M. Jakóbisiak

Research output: Contribution to journal › Article › peer-review

Abstract

Granulocyte colony-stimulating factor (G-CSF) was found to exert antitumor activity against murine MmB 16 melanoma when administered intratumorally. However, subcutaneous administration of this cytokine at a site distant from the growing tumor did not show any antitumor effects. G- CSF did not influence the proliferative activity of MmB 16 in vitro. Intraperitoneal administration of G-CSF resulted in decreased secretion of nitric oxide (NO) by peritoneal macrophages and their decreased tumoricidal activity against MmB 16.

Original language	English (US)
Pages (from-to)	35-39
Number of pages	5
Journal	Neoplasma
Volume	45
Issue number	1
State	Published - 1998
Externally published	Yes

Keywords

Granulocyte colony-stimulating factor
Macrophages
Melanoma MmB16
Nitric oxide

ASJC Scopus subject areas

Cancer Research

Cite this

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title = "Granulocyte colony-stimulating factor demonstrates antitumor activity in melanoma model in mice",

abstract = "Granulocyte colony-stimulating factor (G-CSF) was found to exert antitumor activity against murine MmB 16 melanoma when administered intratumorally. However, subcutaneous administration of this cytokine at a site distant from the growing tumor did not show any antitumor effects. G- CSF did not influence the proliferative activity of MmB 16 in vitro. Intraperitoneal administration of G-CSF resulted in decreased secretion of nitric oxide (NO) by peritoneal macrophages and their decreased tumoricidal activity against MmB 16.",

keywords = "Granulocyte colony-stimulating factor, Macrophages, Melanoma MmB16, Nitric oxide",

author = "J. Go{\l}ab and R. Zago{\'z}dzon and T. Stok{\l}osa and A. Kaca and A. Dabrowska and Adam Giermasz and W. Feleszko and M. Jak{\'o}bisiak",

year = "1998",

language = "English (US)",

volume = "45",

pages = "35--39",

journal = "Neoplasma",

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publisher = "Vydavatel'stvo Slovenkej Akademie Vied/Veda Publishing House of the Slovak Academy of Sciences",

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TY - JOUR

T1 - Granulocyte colony-stimulating factor demonstrates antitumor activity in melanoma model in mice

AU - Gołab, J.

AU - Zagoźdzon, R.

AU - Stokłosa, T.

AU - Kaca, A.

AU - Dabrowska, A.

AU - Giermasz, Adam

AU - Feleszko, W.

AU - Jakóbisiak, M.

PY - 1998

Y1 - 1998

N2 - Granulocyte colony-stimulating factor (G-CSF) was found to exert antitumor activity against murine MmB 16 melanoma when administered intratumorally. However, subcutaneous administration of this cytokine at a site distant from the growing tumor did not show any antitumor effects. G- CSF did not influence the proliferative activity of MmB 16 in vitro. Intraperitoneal administration of G-CSF resulted in decreased secretion of nitric oxide (NO) by peritoneal macrophages and their decreased tumoricidal activity against MmB 16.

AB - Granulocyte colony-stimulating factor (G-CSF) was found to exert antitumor activity against murine MmB 16 melanoma when administered intratumorally. However, subcutaneous administration of this cytokine at a site distant from the growing tumor did not show any antitumor effects. G- CSF did not influence the proliferative activity of MmB 16 in vitro. Intraperitoneal administration of G-CSF resulted in decreased secretion of nitric oxide (NO) by peritoneal macrophages and their decreased tumoricidal activity against MmB 16.

KW - Granulocyte colony-stimulating factor

KW - Macrophages

KW - Melanoma MmB16

KW - Nitric oxide

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ER -

Granulocyte colony-stimulating factor demonstrates antitumor activity in melanoma model in mice

Abstract

Keywords

ASJC Scopus subject areas

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