Graft versus host reaction induced by administration of parental cells

Effect on the autoimmune process of NZB NZW F1 mice

M. Eric Gershwin, Alfred D. Steinberg

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Injection of 6-week-old New Zealand (NZB × NZW F1) female mice with parental NZB or NZW spleen cells leads to acceleration of production of antibodies to both single-stranded DNA and thymocytes and to premature reduction in responsiveness to sheep red blood cells (SRBC) and mitogens. Paradoxically, however, NZB × NZW F1 mice injected with parental cells manifest a significantly reduced level of antibodies to native DNA, reduced proteinuria, and prolonged survival. Moreover, New Zealand mice with chronic graft versus host disease develop splenomegaly and significantly elevated serum immunoglobulin concentrations, but no major propensity to develop excessive lymphomas. Finally, the parental splenic cell type responsible for these features is a thy 1.2 bearing radiation-sensitive cell population. The "immunologic storm" produced by injection of parental cells modifies the expression of autoimmunity such that earlier but less pathogenic autoantibodies are produced.

Original languageEnglish (US)
Pages (from-to)403-413
Number of pages11
JournalClinical Immunology and Immunopathology
Volume10
Issue number4
DOIs
StatePublished - 1978

Fingerprint

Transplants
New Zealand
Injections
Single-Stranded DNA
Splenomegaly
Graft vs Host Disease
Vulnerable Populations
Thymocytes
Autoimmunity
Mitogens
Proteinuria
Autoantibodies
Antibody Formation
Immunoglobulins
Lymphoma
Sheep
Spleen
Erythrocytes
Radiation
Survival

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pathology and Forensic Medicine

Cite this

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abstract = "Injection of 6-week-old New Zealand (NZB × NZW F1) female mice with parental NZB or NZW spleen cells leads to acceleration of production of antibodies to both single-stranded DNA and thymocytes and to premature reduction in responsiveness to sheep red blood cells (SRBC) and mitogens. Paradoxically, however, NZB × NZW F1 mice injected with parental cells manifest a significantly reduced level of antibodies to native DNA, reduced proteinuria, and prolonged survival. Moreover, New Zealand mice with chronic graft versus host disease develop splenomegaly and significantly elevated serum immunoglobulin concentrations, but no major propensity to develop excessive lymphomas. Finally, the parental splenic cell type responsible for these features is a thy 1.2 bearing radiation-sensitive cell population. The {"}immunologic storm{"} produced by injection of parental cells modifies the expression of autoimmunity such that earlier but less pathogenic autoantibodies are produced.",
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AU - Steinberg, Alfred D.

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N2 - Injection of 6-week-old New Zealand (NZB × NZW F1) female mice with parental NZB or NZW spleen cells leads to acceleration of production of antibodies to both single-stranded DNA and thymocytes and to premature reduction in responsiveness to sheep red blood cells (SRBC) and mitogens. Paradoxically, however, NZB × NZW F1 mice injected with parental cells manifest a significantly reduced level of antibodies to native DNA, reduced proteinuria, and prolonged survival. Moreover, New Zealand mice with chronic graft versus host disease develop splenomegaly and significantly elevated serum immunoglobulin concentrations, but no major propensity to develop excessive lymphomas. Finally, the parental splenic cell type responsible for these features is a thy 1.2 bearing radiation-sensitive cell population. The "immunologic storm" produced by injection of parental cells modifies the expression of autoimmunity such that earlier but less pathogenic autoantibodies are produced.

AB - Injection of 6-week-old New Zealand (NZB × NZW F1) female mice with parental NZB or NZW spleen cells leads to acceleration of production of antibodies to both single-stranded DNA and thymocytes and to premature reduction in responsiveness to sheep red blood cells (SRBC) and mitogens. Paradoxically, however, NZB × NZW F1 mice injected with parental cells manifest a significantly reduced level of antibodies to native DNA, reduced proteinuria, and prolonged survival. Moreover, New Zealand mice with chronic graft versus host disease develop splenomegaly and significantly elevated serum immunoglobulin concentrations, but no major propensity to develop excessive lymphomas. Finally, the parental splenic cell type responsible for these features is a thy 1.2 bearing radiation-sensitive cell population. The "immunologic storm" produced by injection of parental cells modifies the expression of autoimmunity such that earlier but less pathogenic autoantibodies are produced.

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