Graft-versus-host disease in limb transplantation: Digital image analysis of bone marrow and TGF-β expression in situ using a novel 3-D microscope

R. Ramsamooj, R. Liull, L. D. Tatem, K. S. Black, V. Lotano, R. M. Dalsey, C. T. Born, W. G. DeLong, C. W. Hewitt

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

A subpopulation of parental to hybrid VBMT recipients developed characteristic clinical and histopathologic manifestations of GVHD. These changes are similar to those seen in human GVHD secondary to bone marrow transplantation. Human GVHD also manifests itself in an acute and chronic manner. Only a minority (30% to 40%) of animals developed lethal GVHD in our model. Those animals developing GVHD had a significantly (P < .0001) higher expression of TGF-β in situ compared to the tolerant subpopulation. The differential expression of TGF-β may represent an important mechanism of immune dysregulation associated with GVHD in CTA recipients.

Original languageEnglish (US)
Pages (from-to)2029-2031
Number of pages3
JournalTransplantation Proceedings
Volume28
Issue number4
StatePublished - 1996
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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    Ramsamooj, R., Liull, R., Tatem, L. D., Black, K. S., Lotano, V., Dalsey, R. M., Born, C. T., DeLong, W. G., & Hewitt, C. W. (1996). Graft-versus-host disease in limb transplantation: Digital image analysis of bone marrow and TGF-β expression in situ using a novel 3-D microscope. Transplantation Proceedings, 28(4), 2029-2031.