The binding of The HIV-1 surface glycoprotein gp120 to several glycosphingolipides, reconstituted into planar lipid bilayers (see scheme; small circle= 2-oleoyl-1-palmitoylphosphatidylcholine (POPC), arrow = glycosylceramide recognition element; left: low and right: high protein concentrations), has been quantitatively measured under quilibrium conditions. Complex binding behavior was observed, which suggests that the induced aggregation of gp120 molecules at a ligand-bearing membrane surface may be an important step in the mechanism of HIV-1 infection of a host cell.
|Original language||English (US)|
|Number of pages||3|
|Journal||Angewandte Chemie - International Edition|
|State||Published - Aug 18 2000|
- Fluorescence spectroscopy
- Structure-activity relationships
ASJC Scopus subject areas