Gorilla genome structural variation reveals evolutionary parallelisms with chimpanzee

Mario Ventura, Claudia R. Catacchio, Can Alkan, Tomas Marques-Bonet, Saba Sajjadian, Tina A. Graves, Fereydoun Hormozdiari, Arcadi Navarro, Maika Malig, Carl Baker, Choli Lee, Emily H. Turner, Lin Chen, Jeffrey M. Kidd, Nicoletta Archidiacono, Jay Shendure, Richard K. Wilson, Evan E. Eichler

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Structural variation has played an important role in the evolutionary restructuring of human and great ape genomes. Recent analyses have suggested that the genomes of chimpanzee and human have been particularly enriched for this form of genetic variation. Here, we set out to assess the extent of structural variation in the gorilla lineage by generating 10-fold genomic sequence coverage from a western lowland gorilla and integrating these data into a physical and cytogenetic framework of structural variation. We discovered and validated over 7665 structural changes within the gorilla lineage, including sequence resolution of inversions, deletions, duplications, and mobile element insertions. A comparison with human and other ape genomes shows that the gorilla genome has been subjected to the highest rate of segmental duplication. We show that both the gorilla and chimpanzee genomes have experienced independent yet convergent patterns of structural mutation that have not occurred in humans, including the formation of subtelomeric heterochromatic caps, the hyperexpansion of segmental duplications, and bursts of retroviral integrations. Our analysis suggests that the chimpanzee and gorilla genomes are structurally more derived than either orangutan or human genomes.

Original languageEnglish (US)
Pages (from-to)1640-1649
Number of pages10
JournalGenome Research
Volume21
Issue number10
DOIs
StatePublished - Oct 1 2011
Externally publishedYes

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Genomic Structural Variation
Gorilla gorilla
Pan troglodytes
Genome
Genomic Segmental Duplications
Hominidae
Human Genome
Pongo
Sequence Inversion
Cytogenetics
Mutation

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Ventura, M., Catacchio, C. R., Alkan, C., Marques-Bonet, T., Sajjadian, S., Graves, T. A., ... Eichler, E. E. (2011). Gorilla genome structural variation reveals evolutionary parallelisms with chimpanzee. Genome Research, 21(10), 1640-1649. https://doi.org/10.1101/gr.124461.111

Gorilla genome structural variation reveals evolutionary parallelisms with chimpanzee. / Ventura, Mario; Catacchio, Claudia R.; Alkan, Can; Marques-Bonet, Tomas; Sajjadian, Saba; Graves, Tina A.; Hormozdiari, Fereydoun; Navarro, Arcadi; Malig, Maika; Baker, Carl; Lee, Choli; Turner, Emily H.; Chen, Lin; Kidd, Jeffrey M.; Archidiacono, Nicoletta; Shendure, Jay; Wilson, Richard K.; Eichler, Evan E.

In: Genome Research, Vol. 21, No. 10, 01.10.2011, p. 1640-1649.

Research output: Contribution to journalArticle

Ventura, M, Catacchio, CR, Alkan, C, Marques-Bonet, T, Sajjadian, S, Graves, TA, Hormozdiari, F, Navarro, A, Malig, M, Baker, C, Lee, C, Turner, EH, Chen, L, Kidd, JM, Archidiacono, N, Shendure, J, Wilson, RK & Eichler, EE 2011, 'Gorilla genome structural variation reveals evolutionary parallelisms with chimpanzee', Genome Research, vol. 21, no. 10, pp. 1640-1649. https://doi.org/10.1101/gr.124461.111
Ventura M, Catacchio CR, Alkan C, Marques-Bonet T, Sajjadian S, Graves TA et al. Gorilla genome structural variation reveals evolutionary parallelisms with chimpanzee. Genome Research. 2011 Oct 1;21(10):1640-1649. https://doi.org/10.1101/gr.124461.111
Ventura, Mario ; Catacchio, Claudia R. ; Alkan, Can ; Marques-Bonet, Tomas ; Sajjadian, Saba ; Graves, Tina A. ; Hormozdiari, Fereydoun ; Navarro, Arcadi ; Malig, Maika ; Baker, Carl ; Lee, Choli ; Turner, Emily H. ; Chen, Lin ; Kidd, Jeffrey M. ; Archidiacono, Nicoletta ; Shendure, Jay ; Wilson, Richard K. ; Eichler, Evan E. / Gorilla genome structural variation reveals evolutionary parallelisms with chimpanzee. In: Genome Research. 2011 ; Vol. 21, No. 10. pp. 1640-1649.
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