Goodpasture's syndrome with negative serology

Collin O'Hara, Joo Young Song, Sanjay M. Mukhopadhyay, Arnold M. Schwartz

Research output: Contribution to journalArticle

Abstract

Goodpasture's syndrome, the syndromic manifestation of antiglomerular basement membrane (anti-GBM) disease, is an uncommon autoimmune phenomenon that typically presents with lung and renal pathology. The classic patient is young with few comorbidities and typically presents dramatically with diffuse alveolar hemorrhage and/or rapid unexplained kidney failure following respiratory infection. Serological tests are traditionally helpful in establishing the diagnosis, but rare cases of anti-GBM disease may be negative for associated serological markers, namely anti-GBM antibody. This case illustrates the classic clinical features of the pulmonary manifestations of anti-GBM disease with negative serological markers confirmed by immunofluorescence of alveolar basement membrane sampled at autopsy.

Original languageEnglish (US)
Pages (from-to)109-112
Number of pages4
JournalPathology Case Reviews
Volume12
Issue number3
DOIs
StatePublished - May 2007
Externally publishedYes

Fingerprint

Anti-Glomerular Basement Membrane Disease
Serology
Basement Membrane
Lung
Serologic Tests
Respiratory Tract Infections
Renal Insufficiency
Fluorescent Antibody Technique
Comorbidity
Autopsy
Pathology
Hemorrhage
Kidney

Keywords

  • Anti-GBM disease
  • Goodpasture's syndrome

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

O'Hara, C., Song, J. Y., Mukhopadhyay, S. M., & Schwartz, A. M. (2007). Goodpasture's syndrome with negative serology. Pathology Case Reviews, 12(3), 109-112. https://doi.org/10.1097/PCR.0b013e31805d0a71

Goodpasture's syndrome with negative serology. / O'Hara, Collin; Song, Joo Young; Mukhopadhyay, Sanjay M.; Schwartz, Arnold M.

In: Pathology Case Reviews, Vol. 12, No. 3, 05.2007, p. 109-112.

Research output: Contribution to journalArticle

O'Hara, C, Song, JY, Mukhopadhyay, SM & Schwartz, AM 2007, 'Goodpasture's syndrome with negative serology', Pathology Case Reviews, vol. 12, no. 3, pp. 109-112. https://doi.org/10.1097/PCR.0b013e31805d0a71
O'Hara C, Song JY, Mukhopadhyay SM, Schwartz AM. Goodpasture's syndrome with negative serology. Pathology Case Reviews. 2007 May;12(3):109-112. https://doi.org/10.1097/PCR.0b013e31805d0a71
O'Hara, Collin ; Song, Joo Young ; Mukhopadhyay, Sanjay M. ; Schwartz, Arnold M. / Goodpasture's syndrome with negative serology. In: Pathology Case Reviews. 2007 ; Vol. 12, No. 3. pp. 109-112.
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