Golimumab and certolizumab: The two new anti-tumor necrosis factor kids on the block

Mohit Mittal, Siba P Raychaudhuri

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Anti-tumor necrosis factor (anti-TNF) agents have revolutionized treatment of psoriasis and many other inflammatory diseases of autoimmune origin. They have considerable advantages over the existing immunomodulators. Anti-TNF agents are designed to target a very specific component of the immune-mediated inflammatory cascades. Thus, they have lower risks of systemic side-effects. In a brief period of 10 years, a growing number of biological therapies are entering the clinical arena while many more biologicals remain on the horizon. With time, the long-term side-effects and efficacies of these individual agents will become clearer and help to determine which ones are the most suitable for long-term care. Golimumab (a human monoclonal anti-TNF-α antibody) and Certolizumab (a PEGylated Fab fragment of humanized monoclonal TNF-α antibody) are the two latest additions to the anti-TNF regimen. Here, we are providing a brief description about these two drugs and their uses.

Original languageEnglish (US)
Pages (from-to)602-609
Number of pages8
JournalIndian Journal of Dermatology, Venereology and Leprology
Volume76
Issue number6
DOIs
StatePublished - Nov 2010

Keywords

  • Anti-tumor necrosis factor agents
  • Certolizumab
  • Golimumab

ASJC Scopus subject areas

  • Dermatology
  • Infectious Diseases

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