Glycoprotein synthesis by an established cell line from hamster tracheal epithelium

Jerold A Last, Tokio Kaizu, Brooke T. Mossman

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

A cloned cell line, HTE-B, derived from hamster tracheal epithelium, synthesizes and secretes labeled glycoproteins in tissue culture. The glycopeptides derived from these glycoproteins by papain treatment are chromatographcally and electrophoretically indistinguishable from those derived from glycoproteins secreted by cultured tracheal explants from rats or humans. The availability of this cell line should allow us to greatly increase our understanding of the mechanisms of glycoprotein synthesis and secretion by respiratory epithelial cells, and the underlying control mechanisms governing these processes.

Original languageEnglish (US)
Pages (from-to)89-98
Number of pages10
JournalExperimental Lung Research
Volume1
Issue number2
DOIs
StatePublished - 1980

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Molecular Biology
  • Clinical Biochemistry

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