TY - JOUR
T1 - Glycomics and disease markers
AU - An, Hyun Joo
AU - Kronewitter, Scott R.
AU - de Leoz, Maria Lorna A
AU - Lebrilla, Carlito B
PY - 2009/12
Y1 - 2009/12
N2 - Glycomics is the comprehensive study of all glycans expressed in biological systems. The biosynthesis of glycan relies on a number of highly competitive processes involving glycosyl transferases. Glycosylation is therefore highly sensitive to the biochemical environment and has been implicated in many diseases including cancer. Recently, interest in profiling the glycome has increased owing to the potential of glycans for disease markers. In this regard, mass spectrometry is emerging as a powerful technique for profiling the glycome. Global glycan profiling of human serum based on mass spectrometry has already led to several potentially promising markers for several types of cancer and diseases.
AB - Glycomics is the comprehensive study of all glycans expressed in biological systems. The biosynthesis of glycan relies on a number of highly competitive processes involving glycosyl transferases. Glycosylation is therefore highly sensitive to the biochemical environment and has been implicated in many diseases including cancer. Recently, interest in profiling the glycome has increased owing to the potential of glycans for disease markers. In this regard, mass spectrometry is emerging as a powerful technique for profiling the glycome. Global glycan profiling of human serum based on mass spectrometry has already led to several potentially promising markers for several types of cancer and diseases.
UR - http://www.scopus.com/inward/record.url?scp=70549113225&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70549113225&partnerID=8YFLogxK
U2 - 10.1016/j.cbpa.2009.08.015
DO - 10.1016/j.cbpa.2009.08.015
M3 - Article
C2 - 19775929
AN - SCOPUS:70549113225
VL - 13
SP - 601
EP - 607
JO - Current Opinion in Chemical Biology
JF - Current Opinion in Chemical Biology
SN - 1367-5931
IS - 5-6
ER -