Glycomics and disease markers

Hyun Joo An, Scott R. Kronewitter, Maria Lorna A de Leoz, Carlito B Lebrilla

Research output: Contribution to journalArticle

198 Scopus citations

Abstract

Glycomics is the comprehensive study of all glycans expressed in biological systems. The biosynthesis of glycan relies on a number of highly competitive processes involving glycosyl transferases. Glycosylation is therefore highly sensitive to the biochemical environment and has been implicated in many diseases including cancer. Recently, interest in profiling the glycome has increased owing to the potential of glycans for disease markers. In this regard, mass spectrometry is emerging as a powerful technique for profiling the glycome. Global glycan profiling of human serum based on mass spectrometry has already led to several potentially promising markers for several types of cancer and diseases.

Original languageEnglish (US)
Pages (from-to)601-607
Number of pages7
JournalCurrent Opinion in Chemical Biology
Volume13
Issue number5-6
DOIs
StatePublished - Dec 2009

ASJC Scopus subject areas

  • Biochemistry
  • Analytical Chemistry

Fingerprint Dive into the research topics of 'Glycomics and disease markers'. Together they form a unique fingerprint.

  • Cite this