Glucocorticoids and skeletal muscle

Sue C. Bodine, John Furlow

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

Glucocorticoids are known to regulate protein metabolism in skeletal muscle, producing a catabolic effect that is opposite that of insulin. In many catabolic diseases, such as sepsis, starvation, and cancer cachexia, endogenous glucocorticoids are elevated contributing to the loss of muscle mass and function. Further, exogenous glucocorticoids are often given acutely and chronically to treat infl ammatory conditions such as asthma, chronic obstructive pulmonary disease, and rheumatoid arthritis, resulting in muscle atrophy. This chapter will detail the nature of glucocorticoid-induced muscle atrophy and discuss the mechanisms thought to be responsible for the catabolic effects of glucocorticoids on muscle.

Original languageEnglish (US)
Pages (from-to)145-176
Number of pages32
JournalAdvances in Experimental Medicine and Biology
Volume872
DOIs
StatePublished - 2015

Keywords

  • Gene transcription
  • Muscle atrophy
  • Pathway
  • Protein synthesis
  • Proteolysis
  • Ubiquitin proteasome

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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