Glucocorticoids and osteocyte autophagy

Wei Yao, Weiwei Dai, Jean X. Jiang, Nancy E Lane

Research output: Contribution to journalArticle

41 Scopus citations

Abstract

Glucocorticoids are used for the treatment of inflammatory and autoimmune diseases. While they are effective therapy, bone loss and incident fracture risk are high. While previous studies have found GC effects on both osteoclasts and osteoblasts, our work has focused on the effects of GCs on osteocytes. Osteocytes exposed to low dose GCs undergo autophagy while osteocytes exposed to high doses of GCs or for a prolonged period of time undergo apoptosis. This paper will review the data to support the role of GCs in osteocyte autophagy. This article is part of a Special Issue entitled "The Osteocyte".

Original languageEnglish (US)
Pages (from-to)279-284
Number of pages6
JournalBone
Volume54
Issue number2
DOIs
StatePublished - Jun 2013

Keywords

  • Autophagy
  • Bone fragility
  • Glucocorticoids

ASJC Scopus subject areas

  • Physiology
  • Endocrinology, Diabetes and Metabolism
  • Histology

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