Glucagon-like peptide 1 interacts with ghrelin and leptin to regulate glucose metabolism and food intake through vagal afferent neuron signaling

Charlotte C. Ronveaux, Daniel Tomé, Helen E Raybould

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

Emerging evidence has suggested a possible physiologic role for peripheral glucagon-like peptide 1 (GLP-1) in regulating glucose metabolism and food intake. The likely site of action of GLP-1 is on vagal afferent neurons (VANs). The vagal afferent pathway is the major neural pathway by which information about ingested nutrients reaches the central nervous system and influences feeding behavior. Peripheral GLP-1 acts on VANs to inhibit food intake. The mechanism of the GLP-1 receptor (GLP-1R) is unlike other gut-derived receptors; GLP-1Rs change their cellular localization according to feeding status rather than their protein concentrations. It is possible that several gut peptides are involved in mediating GLP-1R translocation. The mechanism of peripheral GLP-1R translocation still needs to be elucidated. We review data supporting the role of peripheral GLP-1 acting on VANs in influencing glucose homeostasis and feeding behavior. We highlight evidence demonstrating that GLP-1 interacts with ghrelin and leptin to induce satiation. Our aim was to understand the mechanism of peripheral GLP-1 in the development of noninvasive antiobesity treatments.

Original languageEnglish (US)
Pages (from-to)672-680
Number of pages9
JournalJournal of Nutrition
Volume145
Issue number4
DOIs
StatePublished - 2015

Keywords

  • Food intake
  • Ghrelin
  • Glucagon-like peptide 1
  • Leptin
  • Vagal afferent neurons

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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