Glomerulonephritis in renal allografts associated with hepatitis C infection: A possible relationship with transplant glomerulopathy in two cases

Brian J Gallay, Charles E. Alpers, Connie L. Davis, Michael F. Schultz, Richard J. Johnson

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Chronic infection with hepatitis C virus (HCV) has been identified as a cause of type I membranoproliferative glomerulonephritis (MPGN). HCV infection is common in patients with end-stage renal disease and may persist in renal allograft recipients. MPGN in the allograft may therefore be a manifestation of persistent HCV infection. We report two cases of glomerulopathy with features of both MPGN and transplant glomerulopathy in renal transplant patients chronically infected with HCV. We discuss the course of interferon alfa therapy in both patients as well as a possible relationship of HCV infection with transplant glomerulopathy.

Original languageEnglish (US)
Pages (from-to)662-667
Number of pages6
JournalAmerican Journal of Kidney Diseases
Volume26
Issue number4
DOIs
StatePublished - 1995
Externally publishedYes

Fingerprint

Hepatitis C
Glomerulonephritis
Hepacivirus
Allografts
Membranoproliferative Glomerulonephritis
Transplants
Kidney
Virus Diseases
Infection
Interferon-alpha
Chronic Kidney Failure
Therapeutics

Keywords

  • Hepatitis C virus infection
  • interferon alpha
  • transplant glomerulopathy
  • transplantation

ASJC Scopus subject areas

  • Nephrology

Cite this

Glomerulonephritis in renal allografts associated with hepatitis C infection : A possible relationship with transplant glomerulopathy in two cases. / Gallay, Brian J; Alpers, Charles E.; Davis, Connie L.; Schultz, Michael F.; Johnson, Richard J.

In: American Journal of Kidney Diseases, Vol. 26, No. 4, 1995, p. 662-667.

Research output: Contribution to journalArticle

@article{0ba5132b50904e1a857ef3787d293cfb,
title = "Glomerulonephritis in renal allografts associated with hepatitis C infection: A possible relationship with transplant glomerulopathy in two cases",
abstract = "Chronic infection with hepatitis C virus (HCV) has been identified as a cause of type I membranoproliferative glomerulonephritis (MPGN). HCV infection is common in patients with end-stage renal disease and may persist in renal allograft recipients. MPGN in the allograft may therefore be a manifestation of persistent HCV infection. We report two cases of glomerulopathy with features of both MPGN and transplant glomerulopathy in renal transplant patients chronically infected with HCV. We discuss the course of interferon alfa therapy in both patients as well as a possible relationship of HCV infection with transplant glomerulopathy.",
keywords = "Hepatitis C virus infection, interferon alpha, transplant glomerulopathy, transplantation",
author = "Gallay, {Brian J} and Alpers, {Charles E.} and Davis, {Connie L.} and Schultz, {Michael F.} and Johnson, {Richard J.}",
year = "1995",
doi = "10.1016/0272-6386(95)90606-1",
language = "English (US)",
volume = "26",
pages = "662--667",
journal = "American Journal of Kidney Diseases",
issn = "0272-6386",
publisher = "W.B. Saunders Ltd",
number = "4",

}

TY - JOUR

T1 - Glomerulonephritis in renal allografts associated with hepatitis C infection

T2 - A possible relationship with transplant glomerulopathy in two cases

AU - Gallay, Brian J

AU - Alpers, Charles E.

AU - Davis, Connie L.

AU - Schultz, Michael F.

AU - Johnson, Richard J.

PY - 1995

Y1 - 1995

N2 - Chronic infection with hepatitis C virus (HCV) has been identified as a cause of type I membranoproliferative glomerulonephritis (MPGN). HCV infection is common in patients with end-stage renal disease and may persist in renal allograft recipients. MPGN in the allograft may therefore be a manifestation of persistent HCV infection. We report two cases of glomerulopathy with features of both MPGN and transplant glomerulopathy in renal transplant patients chronically infected with HCV. We discuss the course of interferon alfa therapy in both patients as well as a possible relationship of HCV infection with transplant glomerulopathy.

AB - Chronic infection with hepatitis C virus (HCV) has been identified as a cause of type I membranoproliferative glomerulonephritis (MPGN). HCV infection is common in patients with end-stage renal disease and may persist in renal allograft recipients. MPGN in the allograft may therefore be a manifestation of persistent HCV infection. We report two cases of glomerulopathy with features of both MPGN and transplant glomerulopathy in renal transplant patients chronically infected with HCV. We discuss the course of interferon alfa therapy in both patients as well as a possible relationship of HCV infection with transplant glomerulopathy.

KW - Hepatitis C virus infection

KW - interferon alpha

KW - transplant glomerulopathy

KW - transplantation

UR - http://www.scopus.com/inward/record.url?scp=0029087551&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029087551&partnerID=8YFLogxK

U2 - 10.1016/0272-6386(95)90606-1

DO - 10.1016/0272-6386(95)90606-1

M3 - Article

C2 - 7573024

AN - SCOPUS:0029087551

VL - 26

SP - 662

EP - 667

JO - American Journal of Kidney Diseases

JF - American Journal of Kidney Diseases

SN - 0272-6386

IS - 4

ER -