Glomerular filtration response to acute ureteral obstruction in the dog

Richard W Katzberg; T. W. Morris; P. L. DiMarco; P. A. Merguerian; J. A. Ventura; C. A. Linke; H. W. Fischer

Glomerular filtration response to acute ureteral obstruction in the dog

Richard W Katzberg, T. W. Morris, P. L. DiMarco, P. A. Merguerian, J. A. Ventura, C. A. Linke, H. W. Fischer

Research output: Contribution to journal › Article

Abstract

In order to assess the glomerular filtration responses to acute ureteral obstruction in the dog we employed an established method that does not require timed urine collections. Our results show a 57 per cent increase in renal blood flow (baseline: 203.8 ± 50.9 vs. 319 ± 69.4 ml./min. at 105 minutes; no. = 7) that was associated with a monophasic decrease in filtration fraction to -70 per cent at 120 minutes (0.26 ± 0.025 vs. 0.08 ± 0.007) and an increase in ureteral pressure to 63.1 ± 6.1 mm. Hg at 120 minutes. A biphasic GFR response was noted with an initial small increase (baseline: 32.5 ± 7.5 vs. 36.3 ± 11.0 ml./min. at 2 minutes) followed by a continual decline to -55 per cent at 120 minutes (to 14.5 ± 2.6 ml./min.). This investigation has confirmed the results of micropuncture studies showing maintenance of GFR early after complete ureteral ligation.

Original language	English (US)
Pages (from-to)	1007-1010
Number of pages	4
Journal	Journal of Urology
Volume	134
Issue number	5
State	Published - 1985
Externally published	Yes

ASJC Scopus subject areas

Urology

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Katzberg, R. W., Morris, T. W., DiMarco, P. L., Merguerian, P. A., Ventura, J. A., Linke, C. A., & Fischer, H. W. (1985). Glomerular filtration response to acute ureteral obstruction in the dog. Journal of Urology, 134(5), 1007-1010.

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title = "Glomerular filtration response to acute ureteral obstruction in the dog",

abstract = "In order to assess the glomerular filtration responses to acute ureteral obstruction in the dog we employed an established method that does not require timed urine collections. Our results show a 57 per cent increase in renal blood flow (baseline: 203.8 ± 50.9 vs. 319 ± 69.4 ml./min. at 105 minutes; no. = 7) that was associated with a monophasic decrease in filtration fraction to -70 per cent at 120 minutes (0.26 ± 0.025 vs. 0.08 ± 0.007) and an increase in ureteral pressure to 63.1 ± 6.1 mm. Hg at 120 minutes. A biphasic GFR response was noted with an initial small increase (baseline: 32.5 ± 7.5 vs. 36.3 ± 11.0 ml./min. at 2 minutes) followed by a continual decline to -55 per cent at 120 minutes (to 14.5 ± 2.6 ml./min.). This investigation has confirmed the results of micropuncture studies showing maintenance of GFR early after complete ureteral ligation.",

author = "Katzberg, {Richard W} and Morris, {T. W.} and DiMarco, {P. L.} and Merguerian, {P. A.} and Ventura, {J. A.} and Linke, {C. A.} and Fischer, {H. W.}",

year = "1985",

language = "English (US)",

volume = "134",

pages = "1007--1010",

journal = "Journal of Urology",

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TY - JOUR

T1 - Glomerular filtration response to acute ureteral obstruction in the dog

AU - Katzberg, Richard W

AU - Morris, T. W.

AU - DiMarco, P. L.

AU - Merguerian, P. A.

AU - Ventura, J. A.

AU - Linke, C. A.

AU - Fischer, H. W.

PY - 1985

Y1 - 1985

N2 - In order to assess the glomerular filtration responses to acute ureteral obstruction in the dog we employed an established method that does not require timed urine collections. Our results show a 57 per cent increase in renal blood flow (baseline: 203.8 ± 50.9 vs. 319 ± 69.4 ml./min. at 105 minutes; no. = 7) that was associated with a monophasic decrease in filtration fraction to -70 per cent at 120 minutes (0.26 ± 0.025 vs. 0.08 ± 0.007) and an increase in ureteral pressure to 63.1 ± 6.1 mm. Hg at 120 minutes. A biphasic GFR response was noted with an initial small increase (baseline: 32.5 ± 7.5 vs. 36.3 ± 11.0 ml./min. at 2 minutes) followed by a continual decline to -55 per cent at 120 minutes (to 14.5 ± 2.6 ml./min.). This investigation has confirmed the results of micropuncture studies showing maintenance of GFR early after complete ureteral ligation.

AB - In order to assess the glomerular filtration responses to acute ureteral obstruction in the dog we employed an established method that does not require timed urine collections. Our results show a 57 per cent increase in renal blood flow (baseline: 203.8 ± 50.9 vs. 319 ± 69.4 ml./min. at 105 minutes; no. = 7) that was associated with a monophasic decrease in filtration fraction to -70 per cent at 120 minutes (0.26 ± 0.025 vs. 0.08 ± 0.007) and an increase in ureteral pressure to 63.1 ± 6.1 mm. Hg at 120 minutes. A biphasic GFR response was noted with an initial small increase (baseline: 32.5 ± 7.5 vs. 36.3 ± 11.0 ml./min. at 2 minutes) followed by a continual decline to -55 per cent at 120 minutes (to 14.5 ± 2.6 ml./min.). This investigation has confirmed the results of micropuncture studies showing maintenance of GFR early after complete ureteral ligation.

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