In order to assess the glomerular filtration responses to acute ureteral obstruction in the dog we employed an established method that does not require timed urine collections. Our results show a 57 per cent increase in renal blood flow (baseline: 203.8 ± 50.9 vs. 319 ± 69.4 ml./min. at 105 minutes; no. = 7) that was associated with a monophasic decrease in filtration fraction to -70 per cent at 120 minutes (0.26 ± 0.025 vs. 0.08 ± 0.007) and an increase in ureteral pressure to 63.1 ± 6.1 mm. Hg at 120 minutes. A biphasic GFR response was noted with an initial small increase (baseline: 32.5 ± 7.5 vs. 36.3 ± 11.0 ml./min. at 2 minutes) followed by a continual decline to -55 per cent at 120 minutes (to 14.5 ± 2.6 ml./min.). This investigation has confirmed the results of micropuncture studies showing maintenance of GFR early after complete ureteral ligation.
|Original language||English (US)|
|Number of pages||4|
|Journal||Journal of Urology|
|State||Published - 1985|
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