Global T-wave inversions with isolated hypomagnesemia

Ting F. Tsai, Alyssa C. Browning, John C Rutledge

Research output: Contribution to journalArticlepeer-review


Background: The physiological actions of magnesium within the cardiac conduction system and myocytes have yet to be fully elucidated. Because concurrent hypocalcemia or hypokalemia were also present in previous human reports, specific electrocardiographic effects of isolated hypomagnesemia have not been clearly delineated. Objective: We report a case in which dynamic electrocardiogram (ECG) changes were demonstrated in isolated hypomagnesemia. Case Report: A 37-year-old man with history of heavy alcohol use was admitted for syncope. The ECG showed global T-wave inversions with prolonged corrected QT (QTc) duration on ECG. Extensive work-up including cardiac catheterization was unremarkable. His serum magnesium was noted to be low at 1.1 mg/dL, and his serum calcium and potassium were within normal limits. The patient received magnesium infusion with subsequent ECGs showing resolution of his global T-wave inversions and prolonged QTc. Conclusion: This case is unique because it reports dynamic ECG changes in a patient with isolated hypomagnesemia. Although isolated hypomagnesemia is commonly believed to result in dysrhythmia, we were unaware of any previous cases of ECG abnormalities in humans. Clinically, we advise checking serum magnesium and correcting hypomagnesemia when prolonged QTc duration and global T-wave inversions are seen on ECG.

Original languageEnglish (US)
JournalJournal of Emergency Medicine
Issue number4
StatePublished - Oct 2013


  • electrocardiogram
  • electrolyte abnormalities
  • hypomagnesemia
  • T-wave inversions

ASJC Scopus subject areas

  • Emergency Medicine


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