Abstract
We tested the hypothesis that global functional coupling of resting cortical electroencephalographic (EEG) rhythms is abnormal in amnesic mild cognitive impairment (MCI) patients with remarkable lesions along the cholinergic white-matter tracts. We used the eyes-closed resting EEG data (10-20 montage) of the same groups of 28 healthy elderly (Nold) and 57 MCI subjects of a previous reference study. The estimation of the cholinergic lesion was performed with a validated semi-automatic algorithm based on fluid-attenuated inversion recovery sequences on MRI. The MCI patients were divided into groups of high (MCI+; n=28) and low (MCI-; n=29) cholinergic damage. EEG rhythms of interest were delta (2-4 Hz), theta (4-8 Hz), alpha1 (8-10.5 Hz), alpha2 (10.5-13 Hz), beta1 (13-20 Hz), beta2 (20-30 Hz), and gamma (30- 40 Hz). The global functional coupling of the EEG rhythms was indexed computing the spectral coherence between each electrode and the other 18 electrodes ("electrode" coherence) and then averaging the "electrode" coherence of all 19 electrodes (total coherence). Total coherence of alpha1 rhythms was highest in the Nold, intermediate in the MCI-, and lowest in the MCI+ groups. Furthermore, the alpha1 total coherence was negatively correlated to (moderate to high) cholinergic lesion across the MCI subjects. In conclusion, damage to the cholinergic system is associated with alterations of the functional global coupling of resting alpha rhythms.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 859-871 |
| Number of pages | 13 |
| Journal | Journal of Alzheimer's Disease |
| Volume | 19 |
| Issue number | 3 |
| DOIs | |
| State | Published - 2010 |
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Keywords
- Amnesic mild cognitive impairment
- Cholinergic system
- EEG rhythms
- Electroencephalography
- Magnetic resonance imaging
- Mini Mental State Examination
- Spectral coherence
- Total coherence
- White-matter vascular lesion
ASJC Scopus subject areas
- Psychiatry and Mental health
- Geriatrics and Gerontology
- Clinical Psychology
Cite this
Global functional coupling of resting EEG rhythms is related to white-matter lesions along the cholinergic tracts in subjects with amnesic mild cognitive impairment. / Babiloni, Claudio; Frisoni, Giovanni B.; Vecchio, Fabrizio; Pievani, Michela; Geroldi, Cristina; DeCarli, Charles; Ferri, Raffaele; Vernieri, Fabrizio; Lizio, Roberta; Rossini, Paolo M.
In: Journal of Alzheimer's Disease, Vol. 19, No. 3, 2010, p. 859-871.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Global functional coupling of resting EEG rhythms is related to white-matter lesions along the cholinergic tracts in subjects with amnesic mild cognitive impairment
AU - Babiloni, Claudio
AU - Frisoni, Giovanni B.
AU - Vecchio, Fabrizio
AU - Pievani, Michela
AU - Geroldi, Cristina
AU - DeCarli, Charles
AU - Ferri, Raffaele
AU - Vernieri, Fabrizio
AU - Lizio, Roberta
AU - Rossini, Paolo M.
PY - 2010
Y1 - 2010
N2 - We tested the hypothesis that global functional coupling of resting cortical electroencephalographic (EEG) rhythms is abnormal in amnesic mild cognitive impairment (MCI) patients with remarkable lesions along the cholinergic white-matter tracts. We used the eyes-closed resting EEG data (10-20 montage) of the same groups of 28 healthy elderly (Nold) and 57 MCI subjects of a previous reference study. The estimation of the cholinergic lesion was performed with a validated semi-automatic algorithm based on fluid-attenuated inversion recovery sequences on MRI. The MCI patients were divided into groups of high (MCI+; n=28) and low (MCI-; n=29) cholinergic damage. EEG rhythms of interest were delta (2-4 Hz), theta (4-8 Hz), alpha1 (8-10.5 Hz), alpha2 (10.5-13 Hz), beta1 (13-20 Hz), beta2 (20-30 Hz), and gamma (30- 40 Hz). The global functional coupling of the EEG rhythms was indexed computing the spectral coherence between each electrode and the other 18 electrodes ("electrode" coherence) and then averaging the "electrode" coherence of all 19 electrodes (total coherence). Total coherence of alpha1 rhythms was highest in the Nold, intermediate in the MCI-, and lowest in the MCI+ groups. Furthermore, the alpha1 total coherence was negatively correlated to (moderate to high) cholinergic lesion across the MCI subjects. In conclusion, damage to the cholinergic system is associated with alterations of the functional global coupling of resting alpha rhythms.
AB - We tested the hypothesis that global functional coupling of resting cortical electroencephalographic (EEG) rhythms is abnormal in amnesic mild cognitive impairment (MCI) patients with remarkable lesions along the cholinergic white-matter tracts. We used the eyes-closed resting EEG data (10-20 montage) of the same groups of 28 healthy elderly (Nold) and 57 MCI subjects of a previous reference study. The estimation of the cholinergic lesion was performed with a validated semi-automatic algorithm based on fluid-attenuated inversion recovery sequences on MRI. The MCI patients were divided into groups of high (MCI+; n=28) and low (MCI-; n=29) cholinergic damage. EEG rhythms of interest were delta (2-4 Hz), theta (4-8 Hz), alpha1 (8-10.5 Hz), alpha2 (10.5-13 Hz), beta1 (13-20 Hz), beta2 (20-30 Hz), and gamma (30- 40 Hz). The global functional coupling of the EEG rhythms was indexed computing the spectral coherence between each electrode and the other 18 electrodes ("electrode" coherence) and then averaging the "electrode" coherence of all 19 electrodes (total coherence). Total coherence of alpha1 rhythms was highest in the Nold, intermediate in the MCI-, and lowest in the MCI+ groups. Furthermore, the alpha1 total coherence was negatively correlated to (moderate to high) cholinergic lesion across the MCI subjects. In conclusion, damage to the cholinergic system is associated with alterations of the functional global coupling of resting alpha rhythms.
KW - Amnesic mild cognitive impairment
KW - Cholinergic system
KW - EEG rhythms
KW - Electroencephalography
KW - Magnetic resonance imaging
KW - Mini Mental State Examination
KW - Spectral coherence
KW - Total coherence
KW - White-matter vascular lesion
UR - http://www.scopus.com/inward/record.url?scp=77149123323&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77149123323&partnerID=8YFLogxK
U2 - 10.3233/JAD-2010-1290
DO - 10.3233/JAD-2010-1290
M3 - Article
C2 - 20157242
AN - SCOPUS:77149123323
VL - 19
SP - 859
EP - 871
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
SN - 1387-2877
IS - 3
ER -