Abstract
Primary spinal glioblastoma multiforme (GBM) of the conus medullaris is a rare and devastating pathologic entity. The presenting symptoms commonly include progressive neurologic deficits in the lower extremities, bowel and bladder dysfunction, and low back pain. Histologically, these tumors have high-grade features similar to their intracranial counterparts. However, recent advancements in the field of molecular oncology have been beginning to elucidate a unique molecular blueprint for these spinal gliomas. Given the lack of standardized treatment strategies, we have presented our institutional experience in treating a small series of patients with conus medullaris GBM and have reviewed the reported data on the relevant molecular markers, management strategies, and complication avoidance for this malignant pathologic entity.
Original language | English (US) |
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Pages (from-to) | 101-109 |
Number of pages | 9 |
Journal | World Neurosurgery |
Volume | 124 |
DOIs | |
State | Published - Apr 1 2019 |
Keywords
- Conus medullaris
- Glioblastoma multiforme
- Intramedullary tumor
- Spinal glioma
- Spinal tumor
ASJC Scopus subject areas
- Surgery
- Clinical Neurology