Glioblastoma Multiforme of the Conus Medullaris—Management Strategies and Complications

Amir Goodarzi, Bart Thaci, Atrin Toussi, Tejas Karnati, Kee D Kim, Ruben C Fragoso

Research output: Contribution to journalReview article

Abstract

Primary spinal glioblastoma multiforme (GBM) of the conus medullaris is a rare and devastating pathologic entity. The presenting symptoms commonly include progressive neurologic deficits in the lower extremities, bowel and bladder dysfunction, and low back pain. Histologically, these tumors have high-grade features similar to their intracranial counterparts. However, recent advancements in the field of molecular oncology have been beginning to elucidate a unique molecular blueprint for these spinal gliomas. Given the lack of standardized treatment strategies, we have presented our institutional experience in treating a small series of patients with conus medullaris GBM and have reviewed the reported data on the relevant molecular markers, management strategies, and complication avoidance for this malignant pathologic entity.

Original languageEnglish (US)
Pages (from-to)101-109
Number of pages9
JournalWorld Neurosurgery
Volume124
DOIs
StatePublished - Apr 1 2019

Keywords

  • Conus medullaris
  • Glioblastoma multiforme
  • Intramedullary tumor
  • Spinal glioma
  • Spinal tumor

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Glioblastoma Multiforme of the Conus Medullaris—Management Strategies and Complications'. Together they form a unique fingerprint.

  • Cite this