Glioblastoma multiforme: Clinical findings, magnetic resonance imaging, and pathology in five dogs

D. Lipsitz, Robert Higgins, G. D. Kortz, Peter J Dickinson, A. W. Bollen, D. K. Naydan, Richard A Lecouteur

Research output: Contribution to journalArticle

101 Citations (Scopus)

Abstract

Although glioblastoma multiforme (GBM), a World Health Organization grade IV astrocytoma, is the most common primary brain tumor in humans, in dogs GBM is relatively rare, accounting for only about 5% of all astrocytomas. This study presents combined clinical, neuroimaging, and neuropathologic findings in five dogs with GBM. The five dogs, aged from 5 to 12 years, were presented with progressive neurologic deficits that subsequent clinical neurologic examination and neuroimaging studies by magnetic resonance imaging (MRI), localized to space occupying lesions in the brain. MRI features of the tumors included consistent peritumoral edema (n = 5), sharp borders (n = 4), ring enhancement (n = 3), heterogenous T2-weighted signal intensity (n = 3), iso- to hypointense T1-weighted images (n = 5), necrosis (n = 5), and cyst formation (n = 2). Two tumors were diagnosed clinically using a computed tomography-guided stereotactic biopsy procedure. At necropsy all the tumors resulted in, on transverse sections, a prominent midline shift and had a variegated appearance due to intratumoral necrosis and hemorrhage. Histologically, they had serpentine necrosis with glial cell pseudopalisading and microvascular proliferation, features which distinguish human GBM from grade III astrocytomas. Immunoreactivity of tumor cells for glial fibrillary acidic protein was strongly positive in all cases, whereas 60% and 40% of the tumors also expressed epidermal growth factor receptor and vascular endothelial growth factor, respectively. These canine GBMs shared many diagnostic neuroimaging, gross, microcopic, and immunoreactivity features similar to those of human GBMs.

Original languageEnglish (US)
Pages (from-to)659-669
Number of pages11
JournalVeterinary Pathology
Volume40
Issue number6
DOIs
StatePublished - Nov 2003

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Glioblastoma
magnetic resonance imaging
Magnetic Resonance Imaging
Dogs
Pathology
neoplasms
Neuroimaging
dogs
necrosis
Necrosis
Astrocytoma
neuroglia
Neoplasms
brain
vascular endothelial growth factors
Glial Fibrillary Acidic Protein
Neurologic Examination
World Health Organization
Neurologic Manifestations
computed tomography

Keywords

  • Astrocytoma
  • Brain tumor
  • EGFR
  • Glioblastoma multiforme
  • Immunocytochemistry
  • Magnetic resonance imaging
  • VEGF

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Glioblastoma multiforme : Clinical findings, magnetic resonance imaging, and pathology in five dogs. / Lipsitz, D.; Higgins, Robert; Kortz, G. D.; Dickinson, Peter J; Bollen, A. W.; Naydan, D. K.; Lecouteur, Richard A.

In: Veterinary Pathology, Vol. 40, No. 6, 11.2003, p. 659-669.

Research output: Contribution to journalArticle

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