Glial proteins in canine distemper virus-induced demyelination - A sequential immunocytochemical study

M. Vandevelde, P. Bichsel, S. Cerruti-Sola, A. Steck, F. Kristensen, Robert Higgins

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

A temporal series of demyelinating lesions in experimental canine distemper virus (CDV) infection was examined with immunohistological techniques demonstrating myelin basic protein (MBP), myelin-associated glycoprotein (MAG), and glial fibrillary acidic protein (GFAP) on serial sections. The earliest lesions were characterized by decreased MBP and MAG and increased GFAP. During the further progression of the disease, MBP and MAG losses continued to match each other. There was no indication of MAG loss preceding the disappearance of MBP. In the more advanced lesions there was a marked decrease of GFAP positive cells. Since these findings differed considerably from similar immunohistochemical studies in progressive multifocal leukoencephalopathy (PML) where demyelination results from oligodendroglial infection, it was concluded that the oligodendroglial cell body is not the primary target of CDV. The marked astroglial changes were also considered to contribute to demyelination in CDV infection but the mechanism by which this happens remains unknown.

Original languageEnglish (US)
Pages (from-to)269-276
Number of pages8
JournalActa Neuropathologica
Volume59
Issue number4
DOIs
StatePublished - Dec 1 1983
Externally publishedYes

Keywords

  • Canine distemper
  • Demyelination
  • GFAP
  • Immunohistology
  • MAG
  • MBP

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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