Glaucoma with Descemet's membrane detachment in five horses

Michala de Linde Henriksen, Noelle La Croix, David A. Wilkie, Mary Utter, Karen R. Brantman, Gillian L. Beamer, Leandro B.C. Teixeira, Richard R. Dubielzig

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: To describe the clinical and histopathologic features of glaucoma associated with Descemet's membrane (DM) detachment in five horses without prior history of intraocular surgery. Animals studied: Three Appaloosa horses and two Thoroughbreds were included in this study. The affected horses ranged in age from 16 to 27 years and presented with severe diffuse corneal edema. Procedure: Five eyes were enucleated due to intraocular hypertension and/or chronic corneal ulceration. The enucleated globes were evaluated by the Comparative Ocular Pathology Laboratory of Wisconsin (COPLOW). Each globe was routinely processed for histopathology and analyzed by light microscopy. A histologic diagnosis of glaucoma was reached by demonstrating a loss of optic nerve axonal tissue by measuring neurofilament-immunopositive axons with automated image analysis software. Results: All five horses presented with unilateral severe diffuse corneal edema that had developed between 2 and 16 weeks prior to enucleation. Intraocular pressures for the affected eyes were between 9 and 87 mmHg prior to enucleation. Descemet's membrane detachment was identified histopathologically in all five globes (5/5, 100%). All five eyes had an avascular spindle cell proliferation filling the space between the displaced peripheral DM and the corneal stroma. Neurofilament immunostaining revealed axonal loss consistent with glaucoma. Conclusion: Equine glaucoma may be associated with Descemet's membrane detachment. This detachment and glaucoma is a possible differential diagnosis for severe equine corneal edema. In this case series, an eye with a DM detachment had a poor prognosis for retention.

Original languageEnglish (US)
Pages (from-to)273-279
Number of pages7
JournalVeterinary Ophthalmology
Volume20
Issue number3
DOIs
StatePublished - May 1 2017

Fingerprint

Descemet Membrane
glaucoma
Glaucoma
Horses
Corneal Edema
horses
eyes
edema
Intermediate Filaments
Appaloosa
Corneal Stroma
Nerve Tissue
Optic Nerve
optics
Intraocular Pressure
axons
histopathology
hypertension
prognosis
Axons

Keywords

  • corneal edema
  • Descemet's membrane detachment
  • equine
  • glaucoma
  • ocular hypertension
  • ophthalmology

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Henriksen, M. D. L., La Croix, N., Wilkie, D. A., Utter, M., Brantman, K. R., Beamer, G. L., ... Dubielzig, R. R. (2017). Glaucoma with Descemet's membrane detachment in five horses. Veterinary Ophthalmology, 20(3), 273-279. https://doi.org/10.1111/vop.12388

Glaucoma with Descemet's membrane detachment in five horses. / Henriksen, Michala de Linde; La Croix, Noelle; Wilkie, David A.; Utter, Mary; Brantman, Karen R.; Beamer, Gillian L.; Teixeira, Leandro B.C.; Dubielzig, Richard R.

In: Veterinary Ophthalmology, Vol. 20, No. 3, 01.05.2017, p. 273-279.

Research output: Contribution to journalArticle

Henriksen, MDL, La Croix, N, Wilkie, DA, Utter, M, Brantman, KR, Beamer, GL, Teixeira, LBC & Dubielzig, RR 2017, 'Glaucoma with Descemet's membrane detachment in five horses', Veterinary Ophthalmology, vol. 20, no. 3, pp. 273-279. https://doi.org/10.1111/vop.12388
Henriksen MDL, La Croix N, Wilkie DA, Utter M, Brantman KR, Beamer GL et al. Glaucoma with Descemet's membrane detachment in five horses. Veterinary Ophthalmology. 2017 May 1;20(3):273-279. https://doi.org/10.1111/vop.12388
Henriksen, Michala de Linde ; La Croix, Noelle ; Wilkie, David A. ; Utter, Mary ; Brantman, Karen R. ; Beamer, Gillian L. ; Teixeira, Leandro B.C. ; Dubielzig, Richard R. / Glaucoma with Descemet's membrane detachment in five horses. In: Veterinary Ophthalmology. 2017 ; Vol. 20, No. 3. pp. 273-279.
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N2 - Purpose: To describe the clinical and histopathologic features of glaucoma associated with Descemet's membrane (DM) detachment in five horses without prior history of intraocular surgery. Animals studied: Three Appaloosa horses and two Thoroughbreds were included in this study. The affected horses ranged in age from 16 to 27 years and presented with severe diffuse corneal edema. Procedure: Five eyes were enucleated due to intraocular hypertension and/or chronic corneal ulceration. The enucleated globes were evaluated by the Comparative Ocular Pathology Laboratory of Wisconsin (COPLOW). Each globe was routinely processed for histopathology and analyzed by light microscopy. A histologic diagnosis of glaucoma was reached by demonstrating a loss of optic nerve axonal tissue by measuring neurofilament-immunopositive axons with automated image analysis software. Results: All five horses presented with unilateral severe diffuse corneal edema that had developed between 2 and 16 weeks prior to enucleation. Intraocular pressures for the affected eyes were between 9 and 87 mmHg prior to enucleation. Descemet's membrane detachment was identified histopathologically in all five globes (5/5, 100%). All five eyes had an avascular spindle cell proliferation filling the space between the displaced peripheral DM and the corneal stroma. Neurofilament immunostaining revealed axonal loss consistent with glaucoma. Conclusion: Equine glaucoma may be associated with Descemet's membrane detachment. This detachment and glaucoma is a possible differential diagnosis for severe equine corneal edema. In this case series, an eye with a DM detachment had a poor prognosis for retention.

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