Giant cell tumor of bone

Derek F. Amanatullah, Tyler R. Clark, Matthew J. Lopez, Dariusz Borys, Robert M. Tamurian

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Giant cell tumor of bone (GCT) is a benign, locally aggressive bone tumor. Giant cell tumor of bone primarily affects the young adult patient population. The natural history of GCT is progressive bone destruction leading to joint deformity and disability. Surgery is the primary mode of treatment, but GCT has a tendency to recur locally despite a range of adjuvant surgical options. Pulmonary metastasis has been described. However, systemic spread of GCT rarely becomes progressive, leading to death. This review presents the clinicopathologic features of GCT and a historical perspective that highlights the current rationale and contro-versies regarding the treatment of GCT.

Original languageEnglish (US)
Pages (from-to)112-120
Number of pages9
JournalOrthopedics
Volume37
Issue number2
DOIs
StatePublished - Feb 2014
Externally publishedYes

Fingerprint

Giant Cell Tumor of Bone
Bone and Bones
Young Adult
Joints
Neoplasm Metastasis
Lung
Therapeutics

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

Cite this

Amanatullah, D. F., Clark, T. R., Lopez, M. J., Borys, D., & Tamurian, R. M. (2014). Giant cell tumor of bone. Orthopedics, 37(2), 112-120. https://doi.org/10.3928/01477447-20140124-08

Giant cell tumor of bone. / Amanatullah, Derek F.; Clark, Tyler R.; Lopez, Matthew J.; Borys, Dariusz; Tamurian, Robert M.

In: Orthopedics, Vol. 37, No. 2, 02.2014, p. 112-120.

Research output: Contribution to journalArticle

Amanatullah, DF, Clark, TR, Lopez, MJ, Borys, D & Tamurian, RM 2014, 'Giant cell tumor of bone', Orthopedics, vol. 37, no. 2, pp. 112-120. https://doi.org/10.3928/01477447-20140124-08
Amanatullah DF, Clark TR, Lopez MJ, Borys D, Tamurian RM. Giant cell tumor of bone. Orthopedics. 2014 Feb;37(2):112-120. https://doi.org/10.3928/01477447-20140124-08
Amanatullah, Derek F. ; Clark, Tyler R. ; Lopez, Matthew J. ; Borys, Dariusz ; Tamurian, Robert M. / Giant cell tumor of bone. In: Orthopedics. 2014 ; Vol. 37, No. 2. pp. 112-120.
@article{7dd281fb385843a293015355f16f8e5b,
title = "Giant cell tumor of bone",
abstract = "Giant cell tumor of bone (GCT) is a benign, locally aggressive bone tumor. Giant cell tumor of bone primarily affects the young adult patient population. The natural history of GCT is progressive bone destruction leading to joint deformity and disability. Surgery is the primary mode of treatment, but GCT has a tendency to recur locally despite a range of adjuvant surgical options. Pulmonary metastasis has been described. However, systemic spread of GCT rarely becomes progressive, leading to death. This review presents the clinicopathologic features of GCT and a historical perspective that highlights the current rationale and contro-versies regarding the treatment of GCT.",
author = "Amanatullah, {Derek F.} and Clark, {Tyler R.} and Lopez, {Matthew J.} and Dariusz Borys and Tamurian, {Robert M.}",
year = "2014",
month = "2",
doi = "10.3928/01477447-20140124-08",
language = "English (US)",
volume = "37",
pages = "112--120",
journal = "Orthopedics",
issn = "0147-7447",
publisher = "Slack Incorporated",
number = "2",

}

TY - JOUR

T1 - Giant cell tumor of bone

AU - Amanatullah, Derek F.

AU - Clark, Tyler R.

AU - Lopez, Matthew J.

AU - Borys, Dariusz

AU - Tamurian, Robert M.

PY - 2014/2

Y1 - 2014/2

N2 - Giant cell tumor of bone (GCT) is a benign, locally aggressive bone tumor. Giant cell tumor of bone primarily affects the young adult patient population. The natural history of GCT is progressive bone destruction leading to joint deformity and disability. Surgery is the primary mode of treatment, but GCT has a tendency to recur locally despite a range of adjuvant surgical options. Pulmonary metastasis has been described. However, systemic spread of GCT rarely becomes progressive, leading to death. This review presents the clinicopathologic features of GCT and a historical perspective that highlights the current rationale and contro-versies regarding the treatment of GCT.

AB - Giant cell tumor of bone (GCT) is a benign, locally aggressive bone tumor. Giant cell tumor of bone primarily affects the young adult patient population. The natural history of GCT is progressive bone destruction leading to joint deformity and disability. Surgery is the primary mode of treatment, but GCT has a tendency to recur locally despite a range of adjuvant surgical options. Pulmonary metastasis has been described. However, systemic spread of GCT rarely becomes progressive, leading to death. This review presents the clinicopathologic features of GCT and a historical perspective that highlights the current rationale and contro-versies regarding the treatment of GCT.

UR - http://www.scopus.com/inward/record.url?scp=84893839352&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84893839352&partnerID=8YFLogxK

U2 - 10.3928/01477447-20140124-08

DO - 10.3928/01477447-20140124-08

M3 - Article

C2 - 24679193

AN - SCOPUS:84893839352

VL - 37

SP - 112

EP - 120

JO - Orthopedics

JF - Orthopedics

SN - 0147-7447

IS - 2

ER -