Giant cell tumor of bone

Derek F. Amanatullah, Tyler R. Clark, Matthew J. Lopez, Dariusz Borys, Robert M. Tamurian

Research output: Contribution to journalArticlepeer-review

52 Scopus citations


Giant cell tumor of bone (GCT) is a benign, locally aggressive bone tumor. Giant cell tumor of bone primarily affects the young adult patient population. The natural history of GCT is progressive bone destruction leading to joint deformity and disability. Surgery is the primary mode of treatment, but GCT has a tendency to recur locally despite a range of adjuvant surgical options. Pulmonary metastasis has been described. However, systemic spread of GCT rarely becomes progressive, leading to death. This review presents the clinicopathologic features of GCT and a historical perspective that highlights the current rationale and contro-versies regarding the treatment of GCT.

Original languageEnglish (US)
Pages (from-to)112-120
Number of pages9
Issue number2
StatePublished - Feb 2014
Externally publishedYes

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine


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