Giant cell arteritis: A review of classification, pathophysiology, geoepidemiology and treatment

Andrea T. Borchers, M. Eric Gershwin

Research output: Contribution to journalArticle

126 Citations (Scopus)

Abstract

Giant cell arteritis is a chronic vasculitis affecting large and medium-sized arteries, most commonly the temporal and other cranial arteries. Temporal artery biopsy has long been the gold standard for establishing the diagnosis of giant cell arteritis. There is growing evidence that simultaneous color Doppler and duplex ultrasonography of temporal arteries of GCA patients represents a valid alternative for this somewhat invasive procedure. Ultrasonography and other imaging modalities such as magnetic resonance imaging and positron emission tomography have also provided evidence that involvement of the aorta and its proximal branches is much more common in giant cell arteritis than previously appreciated; it will be important to clarify whether these patients need to be treated more aggressively. It has long been known that patients with giant cell arteritis face a markedly increased risk of developing aortic aneurysms and of dying from aortic dissection. This raises important questions as to whether patients should be screened regularly for extra-cranial large-vessel involvement and whether and how treatment of patients with positive screening results should be adjusted. In this review we discuss the pathophysiology of this disease and also the issues of epidemiology and sex differences.

Original languageEnglish (US)
JournalAutoimmunity Reviews
Volume11
Issue number6-7
DOIs
StatePublished - May 2012

Fingerprint

Giant Cell Arteritis
Temporal Arteries
Doppler Duplex Ultrasonography
Arteries
Therapeutics
Aortic Aneurysm
Vasculitis
Sex Characteristics
Positron-Emission Tomography
Aorta
Dissection
Ultrasonography
Epidemiology
Color
Magnetic Resonance Imaging
Biopsy

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Giant cell arteritis : A review of classification, pathophysiology, geoepidemiology and treatment. / Borchers, Andrea T.; Gershwin, M. Eric.

In: Autoimmunity Reviews, Vol. 11, No. 6-7, 05.2012.

Research output: Contribution to journalArticle

@article{d8753eea4d2e408bba13d0089a616c60,
title = "Giant cell arteritis: A review of classification, pathophysiology, geoepidemiology and treatment",
abstract = "Giant cell arteritis is a chronic vasculitis affecting large and medium-sized arteries, most commonly the temporal and other cranial arteries. Temporal artery biopsy has long been the gold standard for establishing the diagnosis of giant cell arteritis. There is growing evidence that simultaneous color Doppler and duplex ultrasonography of temporal arteries of GCA patients represents a valid alternative for this somewhat invasive procedure. Ultrasonography and other imaging modalities such as magnetic resonance imaging and positron emission tomography have also provided evidence that involvement of the aorta and its proximal branches is much more common in giant cell arteritis than previously appreciated; it will be important to clarify whether these patients need to be treated more aggressively. It has long been known that patients with giant cell arteritis face a markedly increased risk of developing aortic aneurysms and of dying from aortic dissection. This raises important questions as to whether patients should be screened regularly for extra-cranial large-vessel involvement and whether and how treatment of patients with positive screening results should be adjusted. In this review we discuss the pathophysiology of this disease and also the issues of epidemiology and sex differences.",
author = "Borchers, {Andrea T.} and Gershwin, {M. Eric}",
year = "2012",
month = "5",
doi = "10.1016/j.autrev.2012.01.003",
language = "English (US)",
volume = "11",
journal = "Autoimmunity Reviews",
issn = "1568-9972",
publisher = "Elsevier",
number = "6-7",

}

TY - JOUR

T1 - Giant cell arteritis

T2 - A review of classification, pathophysiology, geoepidemiology and treatment

AU - Borchers, Andrea T.

AU - Gershwin, M. Eric

PY - 2012/5

Y1 - 2012/5

N2 - Giant cell arteritis is a chronic vasculitis affecting large and medium-sized arteries, most commonly the temporal and other cranial arteries. Temporal artery biopsy has long been the gold standard for establishing the diagnosis of giant cell arteritis. There is growing evidence that simultaneous color Doppler and duplex ultrasonography of temporal arteries of GCA patients represents a valid alternative for this somewhat invasive procedure. Ultrasonography and other imaging modalities such as magnetic resonance imaging and positron emission tomography have also provided evidence that involvement of the aorta and its proximal branches is much more common in giant cell arteritis than previously appreciated; it will be important to clarify whether these patients need to be treated more aggressively. It has long been known that patients with giant cell arteritis face a markedly increased risk of developing aortic aneurysms and of dying from aortic dissection. This raises important questions as to whether patients should be screened regularly for extra-cranial large-vessel involvement and whether and how treatment of patients with positive screening results should be adjusted. In this review we discuss the pathophysiology of this disease and also the issues of epidemiology and sex differences.

AB - Giant cell arteritis is a chronic vasculitis affecting large and medium-sized arteries, most commonly the temporal and other cranial arteries. Temporal artery biopsy has long been the gold standard for establishing the diagnosis of giant cell arteritis. There is growing evidence that simultaneous color Doppler and duplex ultrasonography of temporal arteries of GCA patients represents a valid alternative for this somewhat invasive procedure. Ultrasonography and other imaging modalities such as magnetic resonance imaging and positron emission tomography have also provided evidence that involvement of the aorta and its proximal branches is much more common in giant cell arteritis than previously appreciated; it will be important to clarify whether these patients need to be treated more aggressively. It has long been known that patients with giant cell arteritis face a markedly increased risk of developing aortic aneurysms and of dying from aortic dissection. This raises important questions as to whether patients should be screened regularly for extra-cranial large-vessel involvement and whether and how treatment of patients with positive screening results should be adjusted. In this review we discuss the pathophysiology of this disease and also the issues of epidemiology and sex differences.

UR - http://www.scopus.com/inward/record.url?scp=84858440886&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84858440886&partnerID=8YFLogxK

U2 - 10.1016/j.autrev.2012.01.003

DO - 10.1016/j.autrev.2012.01.003

M3 - Article

C2 - 22285588

AN - SCOPUS:84858440886

VL - 11

JO - Autoimmunity Reviews

JF - Autoimmunity Reviews

SN - 1568-9972

IS - 6-7

ER -