TY - JOUR
T1 - GHetting to know ADPKD proliferative signaling, STAT
AU - Chen, Ching-Hsien
AU - Weiss, Robert H
PY - 2017/3/1
Y1 - 2017/3/1
N2 - Due to their common pathogenesis and parallel proliferative signaling pathways, the cystic diseases have been recently studied in the context of cancer biology. The present study continues this paradigm by identifying signal transducer and activator of transcription (STAT5) and growth hormone (GH) as potentially modifiable pathways in polycystic kidney disease. GH, which is a potent activator of STAT5, has the additional possibility of being a biomarker, as well as providing a potential mechanism of action of somatostatin analogs in clinical trials.
AB - Due to their common pathogenesis and parallel proliferative signaling pathways, the cystic diseases have been recently studied in the context of cancer biology. The present study continues this paradigm by identifying signal transducer and activator of transcription (STAT5) and growth hormone (GH) as potentially modifiable pathways in polycystic kidney disease. GH, which is a potent activator of STAT5, has the additional possibility of being a biomarker, as well as providing a potential mechanism of action of somatostatin analogs in clinical trials.
UR - http://www.scopus.com/inward/record.url?scp=85012974110&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85012974110&partnerID=8YFLogxK
U2 - 10.1016/j.kint.2016.11.024
DO - 10.1016/j.kint.2016.11.024
M3 - Comment/debate
C2 - 28202165
AN - SCOPUS:85012974110
VL - 91
SP - 524
EP - 526
JO - Kidney International
JF - Kidney International
SN - 0085-2538
IS - 3
ER -