Gestational weight gain charts for different body mass index groups for women in Europe, North America, and Oceania

Susana Santos, Iris Eekhout, Ellis Voerman, Romy Gaillard, Henrique Barros, Marie Aline Charles, Leda Chatzi, Cécile Chevrier, George P. Chrousos, Eva Corpeleijn, Nathalie Costet, Sarah Crozier, Myriam Doyon, Merete Eggesbø, Maria Pia Fantini, Sara Farchi, Francesco Forastiere, Luigi Gagliardi, Vagelis Georgiu, Keith M. GodfreyDavide Gori, Veit Grote, Wojciech Hanke, Irva Hertz-Picciotto, Barbara Heude, Marie France Hivert, Daniel Hryhorczuk, Rae Chi Huang, Hazel Inskip, Todd A. Jusko, Anne M. Karvonen, Berthold Koletzko, Leanne K. Küpers, Hanna Lagström, Debbie A. Lawlor, Irina Lehmann, Maria Jose Lopez-Espinosa, Per Magnus, Renata Majewska, Johanna Mäkelä, Yannis Manios, Sheila W. McDonald, Monique Mommers, Camilla S. Morgen, George Moschonis, Ľubica Murínová, John Newnham, Ellen A. Nohr, Anne Marie Nybo Andersen, Emily Oken, Adriëtte J.J.M. Oostvogels, Agnieszka Pac, Eleni Papadopoulou, Juha Pekkanen, Costanza Pizzi, Kinga Polanska, Daniela Porta, Lorenzo Richiardi, Sheryl L. Rifas-Shiman, Nel Roeleveld, Loreto Santa-Marina, Ana C. Santos, Henriette A. Smit, Thorkild I.A. Sørensen, Marie Standl, Maggie Stanislawski, Camilla Stoltenberg, Elisabeth Thiering, Carel Thijs, Maties Torrent, Suzanne C. Tough, Tomas Trnovec, Marleen M.H.J. Van Gelder, Lenie Van Rossem, Andrea Von Berg, Martine Vrijheid, Tanja G.M. Vrijkotte, Oleksandr Zvinchuk, Stef Van Buuren, Vincent W.V. Jaddoe

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: Gestational weight gain differs according to pre-pregnancy body mass index and is related to the risks of adverse maternal and child health outcomes. Gestational weight gain charts for women in different pre-pregnancy body mass index groups enable identification of women and offspring at risk for adverse health outcomes. We aimed to construct gestational weight gain reference charts for underweight, normal weight, overweight, and grades 1, 2 and 3 obese women and to compare these charts with those obtained in women with uncomplicated term pregnancies. Methods: We used individual participant data from 218,216 pregnant women participating in 33 cohorts from Europe, North America, and Oceania. Of these women, 9065 (4.2%), 148,697 (68.1%), 42,678 (19.6%), 13,084 (6.0%), 3597 (1.6%), and 1095 (0.5%) were underweight, normal weight, overweight, and grades 1, 2, and 3 obese women, respectively. A total of 138, 517 women from 26 cohorts had pregnancies with no hypertensive or diabetic disorders and with term deliveries of appropriate for gestational age at birth infants. Gestational weight gain charts for underweight, normal weight, overweight, and grade 1, 2, and 3 obese women were derived by the Box-Cox t method using the generalized additive model for location, scale, and shape. Results: We observed that gestational weight gain strongly differed per maternal pre-pregnancy body mass index group. The median (interquartile range) gestational weight gain at 40 weeks was 14.2 kg (11.4-17.4) for underweight women, 14.5 kg (11.5-17.7) for normal weight women, 13.9 kg (10.1-17.9) for overweight women, and 11.2 kg (7.0-15.7), 8.7 kg (4.3-13.4) and 6.3 kg (1.9-11.1) for grades 1, 2, and 3 obese women, respectively. The rate of weight gain was lower in the first half than in the second half of pregnancy. No differences in the patterns of weight gain were observed between cohorts or countries. Similar weight gain patterns were observed in mothers without pregnancy complications. Conclusions: Gestational weight gain patterns are strongly related to pre-pregnancy body mass index. The derived charts can be used to assess gestational weight gain in etiological research and as a monitoring tool for weight gain during pregnancy in clinical practice.

Original languageEnglish (US)
Article number201
JournalBMC Medicine
Volume16
Issue number1
DOIs
StatePublished - Nov 5 2018

Fingerprint

Oceania
North America
Weight Gain
Body Mass Index
Pregnancy
Thinness
Weights and Measures
Mothers
Social Identification
Pregnancy Complications
Gestational Age

Keywords

  • Charts
  • Pregnancy
  • References
  • Weight gain

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Santos, S., Eekhout, I., Voerman, E., Gaillard, R., Barros, H., Charles, M. A., ... Jaddoe, V. W. V. (2018). Gestational weight gain charts for different body mass index groups for women in Europe, North America, and Oceania. BMC Medicine, 16(1), [201]. https://doi.org/10.1186/s12916-018-1189-1

Gestational weight gain charts for different body mass index groups for women in Europe, North America, and Oceania. / Santos, Susana; Eekhout, Iris; Voerman, Ellis; Gaillard, Romy; Barros, Henrique; Charles, Marie Aline; Chatzi, Leda; Chevrier, Cécile; Chrousos, George P.; Corpeleijn, Eva; Costet, Nathalie; Crozier, Sarah; Doyon, Myriam; Eggesbø, Merete; Fantini, Maria Pia; Farchi, Sara; Forastiere, Francesco; Gagliardi, Luigi; Georgiu, Vagelis; Godfrey, Keith M.; Gori, Davide; Grote, Veit; Hanke, Wojciech; Hertz-Picciotto, Irva; Heude, Barbara; Hivert, Marie France; Hryhorczuk, Daniel; Huang, Rae Chi; Inskip, Hazel; Jusko, Todd A.; Karvonen, Anne M.; Koletzko, Berthold; Küpers, Leanne K.; Lagström, Hanna; Lawlor, Debbie A.; Lehmann, Irina; Lopez-Espinosa, Maria Jose; Magnus, Per; Majewska, Renata; Mäkelä, Johanna; Manios, Yannis; McDonald, Sheila W.; Mommers, Monique; Morgen, Camilla S.; Moschonis, George; Murínová, Ľubica; Newnham, John; Nohr, Ellen A.; Andersen, Anne Marie Nybo; Oken, Emily; Oostvogels, Adriëtte J.J.M.; Pac, Agnieszka; Papadopoulou, Eleni; Pekkanen, Juha; Pizzi, Costanza; Polanska, Kinga; Porta, Daniela; Richiardi, Lorenzo; Rifas-Shiman, Sheryl L.; Roeleveld, Nel; Santa-Marina, Loreto; Santos, Ana C.; Smit, Henriette A.; Sørensen, Thorkild I.A.; Standl, Marie; Stanislawski, Maggie; Stoltenberg, Camilla; Thiering, Elisabeth; Thijs, Carel; Torrent, Maties; Tough, Suzanne C.; Trnovec, Tomas; Van Gelder, Marleen M.H.J.; Van Rossem, Lenie; Von Berg, Andrea; Vrijheid, Martine; Vrijkotte, Tanja G.M.; Zvinchuk, Oleksandr; Van Buuren, Stef; Jaddoe, Vincent W.V.

In: BMC Medicine, Vol. 16, No. 1, 201, 05.11.2018.

Research output: Contribution to journalArticle

Santos, S, Eekhout, I, Voerman, E, Gaillard, R, Barros, H, Charles, MA, Chatzi, L, Chevrier, C, Chrousos, GP, Corpeleijn, E, Costet, N, Crozier, S, Doyon, M, Eggesbø, M, Fantini, MP, Farchi, S, Forastiere, F, Gagliardi, L, Georgiu, V, Godfrey, KM, Gori, D, Grote, V, Hanke, W, Hertz-Picciotto, I, Heude, B, Hivert, MF, Hryhorczuk, D, Huang, RC, Inskip, H, Jusko, TA, Karvonen, AM, Koletzko, B, Küpers, LK, Lagström, H, Lawlor, DA, Lehmann, I, Lopez-Espinosa, MJ, Magnus, P, Majewska, R, Mäkelä, J, Manios, Y, McDonald, SW, Mommers, M, Morgen, CS, Moschonis, G, Murínová, Ľ, Newnham, J, Nohr, EA, Andersen, AMN, Oken, E, Oostvogels, AJJM, Pac, A, Papadopoulou, E, Pekkanen, J, Pizzi, C, Polanska, K, Porta, D, Richiardi, L, Rifas-Shiman, SL, Roeleveld, N, Santa-Marina, L, Santos, AC, Smit, HA, Sørensen, TIA, Standl, M, Stanislawski, M, Stoltenberg, C, Thiering, E, Thijs, C, Torrent, M, Tough, SC, Trnovec, T, Van Gelder, MMHJ, Van Rossem, L, Von Berg, A, Vrijheid, M, Vrijkotte, TGM, Zvinchuk, O, Van Buuren, S & Jaddoe, VWV 2018, 'Gestational weight gain charts for different body mass index groups for women in Europe, North America, and Oceania', BMC Medicine, vol. 16, no. 1, 201. https://doi.org/10.1186/s12916-018-1189-1
Santos, Susana ; Eekhout, Iris ; Voerman, Ellis ; Gaillard, Romy ; Barros, Henrique ; Charles, Marie Aline ; Chatzi, Leda ; Chevrier, Cécile ; Chrousos, George P. ; Corpeleijn, Eva ; Costet, Nathalie ; Crozier, Sarah ; Doyon, Myriam ; Eggesbø, Merete ; Fantini, Maria Pia ; Farchi, Sara ; Forastiere, Francesco ; Gagliardi, Luigi ; Georgiu, Vagelis ; Godfrey, Keith M. ; Gori, Davide ; Grote, Veit ; Hanke, Wojciech ; Hertz-Picciotto, Irva ; Heude, Barbara ; Hivert, Marie France ; Hryhorczuk, Daniel ; Huang, Rae Chi ; Inskip, Hazel ; Jusko, Todd A. ; Karvonen, Anne M. ; Koletzko, Berthold ; Küpers, Leanne K. ; Lagström, Hanna ; Lawlor, Debbie A. ; Lehmann, Irina ; Lopez-Espinosa, Maria Jose ; Magnus, Per ; Majewska, Renata ; Mäkelä, Johanna ; Manios, Yannis ; McDonald, Sheila W. ; Mommers, Monique ; Morgen, Camilla S. ; Moschonis, George ; Murínová, Ľubica ; Newnham, John ; Nohr, Ellen A. ; Andersen, Anne Marie Nybo ; Oken, Emily ; Oostvogels, Adriëtte J.J.M. ; Pac, Agnieszka ; Papadopoulou, Eleni ; Pekkanen, Juha ; Pizzi, Costanza ; Polanska, Kinga ; Porta, Daniela ; Richiardi, Lorenzo ; Rifas-Shiman, Sheryl L. ; Roeleveld, Nel ; Santa-Marina, Loreto ; Santos, Ana C. ; Smit, Henriette A. ; Sørensen, Thorkild I.A. ; Standl, Marie ; Stanislawski, Maggie ; Stoltenberg, Camilla ; Thiering, Elisabeth ; Thijs, Carel ; Torrent, Maties ; Tough, Suzanne C. ; Trnovec, Tomas ; Van Gelder, Marleen M.H.J. ; Van Rossem, Lenie ; Von Berg, Andrea ; Vrijheid, Martine ; Vrijkotte, Tanja G.M. ; Zvinchuk, Oleksandr ; Van Buuren, Stef ; Jaddoe, Vincent W.V. / Gestational weight gain charts for different body mass index groups for women in Europe, North America, and Oceania. In: BMC Medicine. 2018 ; Vol. 16, No. 1.
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title = "Gestational weight gain charts for different body mass index groups for women in Europe, North America, and Oceania",
abstract = "Background: Gestational weight gain differs according to pre-pregnancy body mass index and is related to the risks of adverse maternal and child health outcomes. Gestational weight gain charts for women in different pre-pregnancy body mass index groups enable identification of women and offspring at risk for adverse health outcomes. We aimed to construct gestational weight gain reference charts for underweight, normal weight, overweight, and grades 1, 2 and 3 obese women and to compare these charts with those obtained in women with uncomplicated term pregnancies. Methods: We used individual participant data from 218,216 pregnant women participating in 33 cohorts from Europe, North America, and Oceania. Of these women, 9065 (4.2{\%}), 148,697 (68.1{\%}), 42,678 (19.6{\%}), 13,084 (6.0{\%}), 3597 (1.6{\%}), and 1095 (0.5{\%}) were underweight, normal weight, overweight, and grades 1, 2, and 3 obese women, respectively. A total of 138, 517 women from 26 cohorts had pregnancies with no hypertensive or diabetic disorders and with term deliveries of appropriate for gestational age at birth infants. Gestational weight gain charts for underweight, normal weight, overweight, and grade 1, 2, and 3 obese women were derived by the Box-Cox t method using the generalized additive model for location, scale, and shape. Results: We observed that gestational weight gain strongly differed per maternal pre-pregnancy body mass index group. The median (interquartile range) gestational weight gain at 40 weeks was 14.2 kg (11.4-17.4) for underweight women, 14.5 kg (11.5-17.7) for normal weight women, 13.9 kg (10.1-17.9) for overweight women, and 11.2 kg (7.0-15.7), 8.7 kg (4.3-13.4) and 6.3 kg (1.9-11.1) for grades 1, 2, and 3 obese women, respectively. The rate of weight gain was lower in the first half than in the second half of pregnancy. No differences in the patterns of weight gain were observed between cohorts or countries. Similar weight gain patterns were observed in mothers without pregnancy complications. Conclusions: Gestational weight gain patterns are strongly related to pre-pregnancy body mass index. The derived charts can be used to assess gestational weight gain in etiological research and as a monitoring tool for weight gain during pregnancy in clinical practice.",
keywords = "Charts, Pregnancy, References, Weight gain",
author = "Susana Santos and Iris Eekhout and Ellis Voerman and Romy Gaillard and Henrique Barros and Charles, {Marie Aline} and Leda Chatzi and C{\'e}cile Chevrier and Chrousos, {George P.} and Eva Corpeleijn and Nathalie Costet and Sarah Crozier and Myriam Doyon and Merete Eggesb{\o} and Fantini, {Maria Pia} and Sara Farchi and Francesco Forastiere and Luigi Gagliardi and Vagelis Georgiu and Godfrey, {Keith M.} and Davide Gori and Veit Grote and Wojciech Hanke and Irva Hertz-Picciotto and Barbara Heude and Hivert, {Marie France} and Daniel Hryhorczuk and Huang, {Rae Chi} and Hazel Inskip and Jusko, {Todd A.} and Karvonen, {Anne M.} and Berthold Koletzko and K{\"u}pers, {Leanne K.} and Hanna Lagstr{\"o}m and Lawlor, {Debbie A.} and Irina Lehmann and Lopez-Espinosa, {Maria Jose} and Per Magnus and Renata Majewska and Johanna M{\"a}kel{\"a} and Yannis Manios and McDonald, {Sheila W.} and Monique Mommers and Morgen, {Camilla S.} and George Moschonis and Ľubica Mur{\'i}nov{\'a} and John Newnham and Nohr, {Ellen A.} and Andersen, {Anne Marie Nybo} and Emily Oken and Oostvogels, {Adri{\"e}tte J.J.M.} and Agnieszka Pac and Eleni Papadopoulou and Juha Pekkanen and Costanza Pizzi and Kinga Polanska and Daniela Porta and Lorenzo Richiardi and Rifas-Shiman, {Sheryl L.} and Nel Roeleveld and Loreto Santa-Marina and Santos, {Ana C.} and Smit, {Henriette A.} and S{\o}rensen, {Thorkild I.A.} and Marie Standl and Maggie Stanislawski and Camilla Stoltenberg and Elisabeth Thiering and Carel Thijs and Maties Torrent and Tough, {Suzanne C.} and Tomas Trnovec and {Van Gelder}, {Marleen M.H.J.} and {Van Rossem}, Lenie and {Von Berg}, Andrea and Martine Vrijheid and Vrijkotte, {Tanja G.M.} and Oleksandr Zvinchuk and {Van Buuren}, Stef and Jaddoe, {Vincent W.V.}",
year = "2018",
month = "11",
day = "5",
doi = "10.1186/s12916-018-1189-1",
language = "English (US)",
volume = "16",
journal = "BMC Medicine",
issn = "1741-7015",
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TY - JOUR

T1 - Gestational weight gain charts for different body mass index groups for women in Europe, North America, and Oceania

AU - Santos, Susana

AU - Eekhout, Iris

AU - Voerman, Ellis

AU - Gaillard, Romy

AU - Barros, Henrique

AU - Charles, Marie Aline

AU - Chatzi, Leda

AU - Chevrier, Cécile

AU - Chrousos, George P.

AU - Corpeleijn, Eva

AU - Costet, Nathalie

AU - Crozier, Sarah

AU - Doyon, Myriam

AU - Eggesbø, Merete

AU - Fantini, Maria Pia

AU - Farchi, Sara

AU - Forastiere, Francesco

AU - Gagliardi, Luigi

AU - Georgiu, Vagelis

AU - Godfrey, Keith M.

AU - Gori, Davide

AU - Grote, Veit

AU - Hanke, Wojciech

AU - Hertz-Picciotto, Irva

AU - Heude, Barbara

AU - Hivert, Marie France

AU - Hryhorczuk, Daniel

AU - Huang, Rae Chi

AU - Inskip, Hazel

AU - Jusko, Todd A.

AU - Karvonen, Anne M.

AU - Koletzko, Berthold

AU - Küpers, Leanne K.

AU - Lagström, Hanna

AU - Lawlor, Debbie A.

AU - Lehmann, Irina

AU - Lopez-Espinosa, Maria Jose

AU - Magnus, Per

AU - Majewska, Renata

AU - Mäkelä, Johanna

AU - Manios, Yannis

AU - McDonald, Sheila W.

AU - Mommers, Monique

AU - Morgen, Camilla S.

AU - Moschonis, George

AU - Murínová, Ľubica

AU - Newnham, John

AU - Nohr, Ellen A.

AU - Andersen, Anne Marie Nybo

AU - Oken, Emily

AU - Oostvogels, Adriëtte J.J.M.

AU - Pac, Agnieszka

AU - Papadopoulou, Eleni

AU - Pekkanen, Juha

AU - Pizzi, Costanza

AU - Polanska, Kinga

AU - Porta, Daniela

AU - Richiardi, Lorenzo

AU - Rifas-Shiman, Sheryl L.

AU - Roeleveld, Nel

AU - Santa-Marina, Loreto

AU - Santos, Ana C.

AU - Smit, Henriette A.

AU - Sørensen, Thorkild I.A.

AU - Standl, Marie

AU - Stanislawski, Maggie

AU - Stoltenberg, Camilla

AU - Thiering, Elisabeth

AU - Thijs, Carel

AU - Torrent, Maties

AU - Tough, Suzanne C.

AU - Trnovec, Tomas

AU - Van Gelder, Marleen M.H.J.

AU - Van Rossem, Lenie

AU - Von Berg, Andrea

AU - Vrijheid, Martine

AU - Vrijkotte, Tanja G.M.

AU - Zvinchuk, Oleksandr

AU - Van Buuren, Stef

AU - Jaddoe, Vincent W.V.

PY - 2018/11/5

Y1 - 2018/11/5

N2 - Background: Gestational weight gain differs according to pre-pregnancy body mass index and is related to the risks of adverse maternal and child health outcomes. Gestational weight gain charts for women in different pre-pregnancy body mass index groups enable identification of women and offspring at risk for adverse health outcomes. We aimed to construct gestational weight gain reference charts for underweight, normal weight, overweight, and grades 1, 2 and 3 obese women and to compare these charts with those obtained in women with uncomplicated term pregnancies. Methods: We used individual participant data from 218,216 pregnant women participating in 33 cohorts from Europe, North America, and Oceania. Of these women, 9065 (4.2%), 148,697 (68.1%), 42,678 (19.6%), 13,084 (6.0%), 3597 (1.6%), and 1095 (0.5%) were underweight, normal weight, overweight, and grades 1, 2, and 3 obese women, respectively. A total of 138, 517 women from 26 cohorts had pregnancies with no hypertensive or diabetic disorders and with term deliveries of appropriate for gestational age at birth infants. Gestational weight gain charts for underweight, normal weight, overweight, and grade 1, 2, and 3 obese women were derived by the Box-Cox t method using the generalized additive model for location, scale, and shape. Results: We observed that gestational weight gain strongly differed per maternal pre-pregnancy body mass index group. The median (interquartile range) gestational weight gain at 40 weeks was 14.2 kg (11.4-17.4) for underweight women, 14.5 kg (11.5-17.7) for normal weight women, 13.9 kg (10.1-17.9) for overweight women, and 11.2 kg (7.0-15.7), 8.7 kg (4.3-13.4) and 6.3 kg (1.9-11.1) for grades 1, 2, and 3 obese women, respectively. The rate of weight gain was lower in the first half than in the second half of pregnancy. No differences in the patterns of weight gain were observed between cohorts or countries. Similar weight gain patterns were observed in mothers without pregnancy complications. Conclusions: Gestational weight gain patterns are strongly related to pre-pregnancy body mass index. The derived charts can be used to assess gestational weight gain in etiological research and as a monitoring tool for weight gain during pregnancy in clinical practice.

AB - Background: Gestational weight gain differs according to pre-pregnancy body mass index and is related to the risks of adverse maternal and child health outcomes. Gestational weight gain charts for women in different pre-pregnancy body mass index groups enable identification of women and offspring at risk for adverse health outcomes. We aimed to construct gestational weight gain reference charts for underweight, normal weight, overweight, and grades 1, 2 and 3 obese women and to compare these charts with those obtained in women with uncomplicated term pregnancies. Methods: We used individual participant data from 218,216 pregnant women participating in 33 cohorts from Europe, North America, and Oceania. Of these women, 9065 (4.2%), 148,697 (68.1%), 42,678 (19.6%), 13,084 (6.0%), 3597 (1.6%), and 1095 (0.5%) were underweight, normal weight, overweight, and grades 1, 2, and 3 obese women, respectively. A total of 138, 517 women from 26 cohorts had pregnancies with no hypertensive or diabetic disorders and with term deliveries of appropriate for gestational age at birth infants. Gestational weight gain charts for underweight, normal weight, overweight, and grade 1, 2, and 3 obese women were derived by the Box-Cox t method using the generalized additive model for location, scale, and shape. Results: We observed that gestational weight gain strongly differed per maternal pre-pregnancy body mass index group. The median (interquartile range) gestational weight gain at 40 weeks was 14.2 kg (11.4-17.4) for underweight women, 14.5 kg (11.5-17.7) for normal weight women, 13.9 kg (10.1-17.9) for overweight women, and 11.2 kg (7.0-15.7), 8.7 kg (4.3-13.4) and 6.3 kg (1.9-11.1) for grades 1, 2, and 3 obese women, respectively. The rate of weight gain was lower in the first half than in the second half of pregnancy. No differences in the patterns of weight gain were observed between cohorts or countries. Similar weight gain patterns were observed in mothers without pregnancy complications. Conclusions: Gestational weight gain patterns are strongly related to pre-pregnancy body mass index. The derived charts can be used to assess gestational weight gain in etiological research and as a monitoring tool for weight gain during pregnancy in clinical practice.

KW - Charts

KW - Pregnancy

KW - References

KW - Weight gain

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U2 - 10.1186/s12916-018-1189-1

DO - 10.1186/s12916-018-1189-1

M3 - Article

C2 - 30396358

AN - SCOPUS:85056143604

VL - 16

JO - BMC Medicine

JF - BMC Medicine

SN - 1741-7015

IS - 1

M1 - 201

ER -