Geometry of adult rat sensory neurons in culture; its modulation by laminin

Takayuki Ito, Gen Sobue, Takeshi Yasuda, Terunori Mitsuma, Akira Takahashi, Koji Kimata

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Geometrical analysis of highly-purified and low-density adult rat dorsal root ganglion (DRG) neuron culture proved that laminin enhanced the total neurite length and the maximal extension of neurites, but did not significantly increase the neurite branching nor soma size particularly after 4 days of culture. Survival rates of adult DRG neurons were not affected by laminin. These results suggest that laminin is a potent modulator of neurite geometry in adult rat DRG neurons, which promotes neurite elongation rather than neurite branching.

Original languageEnglish (US)
Pages (from-to)212-216
Number of pages5
JournalNeuroscience Letters
Volume123
Issue number2
DOIs
StatePublished - Feb 25 1991
Externally publishedYes

Keywords

  • Adult DRG neuron
  • Laminin
  • Neuron culture

ASJC Scopus subject areas

  • Neuroscience(all)

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    Ito, T., Sobue, G., Yasuda, T., Mitsuma, T., Takahashi, A., & Kimata, K. (1991). Geometry of adult rat sensory neurons in culture; its modulation by laminin. Neuroscience Letters, 123(2), 212-216. https://doi.org/10.1016/0304-3940(91)90933-K