Geoepidemiology and autoimmune manifestations of lymphoproliferative disorders

Jacob Sands, Joseph Tuscano

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The pathogenesis of lymphoproliferative disorders represents an underlying dysfunction in lymphocyte development and homeostasis. This typically manifests with the accumulation of lymphocytes in the bone marrow, peripheral blood or lymph nodes and spleen. It has been hypothesized that the mechanism for elimination of dysfunctional and autoreactive lymphocytes is defective and contributes to the pathogenesis of these disorders. Based on this hypothesis, it would not be surprising to find an increased incidence of autoimmune manifestations that are associated with these disorders. Autoimmune paraneoplastic syndromes (PNS) are often the result of a dysfunctional immune response, which is related to an underlying malignant process. While all the PNS that are associated with lymphoproliferative disorders do not have an autoimmune basis, many do. Here we review the literature of PNS associated with lymphoproliferative disorders. A concise overview of each syndrome is provided with a focus on clinical manifestations, diagnostics, pathophysiology, and treatment. While the treatment is typically directed at managing the underlying lymphoproliferative process, and can be assumed to be case throughout this review, there are exceptions that are described within the context of each disorder.

Original languageEnglish (US)
JournalAutoimmunity Reviews
Volume9
Issue number5
DOIs
StatePublished - Mar 2010

Fingerprint

Paraneoplastic Syndromes
Lymphoproliferative Disorders
Lymphocytes
Homeostasis
Spleen
Lymph Nodes
Bone Marrow
Incidence
Therapeutics

Keywords

  • Autoimmune
  • Lymphoproliferative disorders
  • Paraneoplastic

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Geoepidemiology and autoimmune manifestations of lymphoproliferative disorders. / Sands, Jacob; Tuscano, Joseph.

In: Autoimmunity Reviews, Vol. 9, No. 5, 03.2010.

Research output: Contribution to journalArticle

@article{7a2adee21882453fb6430ac365fe2f11,
title = "Geoepidemiology and autoimmune manifestations of lymphoproliferative disorders",
abstract = "The pathogenesis of lymphoproliferative disorders represents an underlying dysfunction in lymphocyte development and homeostasis. This typically manifests with the accumulation of lymphocytes in the bone marrow, peripheral blood or lymph nodes and spleen. It has been hypothesized that the mechanism for elimination of dysfunctional and autoreactive lymphocytes is defective and contributes to the pathogenesis of these disorders. Based on this hypothesis, it would not be surprising to find an increased incidence of autoimmune manifestations that are associated with these disorders. Autoimmune paraneoplastic syndromes (PNS) are often the result of a dysfunctional immune response, which is related to an underlying malignant process. While all the PNS that are associated with lymphoproliferative disorders do not have an autoimmune basis, many do. Here we review the literature of PNS associated with lymphoproliferative disorders. A concise overview of each syndrome is provided with a focus on clinical manifestations, diagnostics, pathophysiology, and treatment. While the treatment is typically directed at managing the underlying lymphoproliferative process, and can be assumed to be case throughout this review, there are exceptions that are described within the context of each disorder.",
keywords = "Autoimmune, Lymphoproliferative disorders, Paraneoplastic",
author = "Jacob Sands and Joseph Tuscano",
year = "2010",
month = "3",
doi = "10.1016/j.autrev.2009.11.009",
language = "English (US)",
volume = "9",
journal = "Autoimmunity Reviews",
issn = "1568-9972",
publisher = "Elsevier",
number = "5",

}

TY - JOUR

T1 - Geoepidemiology and autoimmune manifestations of lymphoproliferative disorders

AU - Sands, Jacob

AU - Tuscano, Joseph

PY - 2010/3

Y1 - 2010/3

N2 - The pathogenesis of lymphoproliferative disorders represents an underlying dysfunction in lymphocyte development and homeostasis. This typically manifests with the accumulation of lymphocytes in the bone marrow, peripheral blood or lymph nodes and spleen. It has been hypothesized that the mechanism for elimination of dysfunctional and autoreactive lymphocytes is defective and contributes to the pathogenesis of these disorders. Based on this hypothesis, it would not be surprising to find an increased incidence of autoimmune manifestations that are associated with these disorders. Autoimmune paraneoplastic syndromes (PNS) are often the result of a dysfunctional immune response, which is related to an underlying malignant process. While all the PNS that are associated with lymphoproliferative disorders do not have an autoimmune basis, many do. Here we review the literature of PNS associated with lymphoproliferative disorders. A concise overview of each syndrome is provided with a focus on clinical manifestations, diagnostics, pathophysiology, and treatment. While the treatment is typically directed at managing the underlying lymphoproliferative process, and can be assumed to be case throughout this review, there are exceptions that are described within the context of each disorder.

AB - The pathogenesis of lymphoproliferative disorders represents an underlying dysfunction in lymphocyte development and homeostasis. This typically manifests with the accumulation of lymphocytes in the bone marrow, peripheral blood or lymph nodes and spleen. It has been hypothesized that the mechanism for elimination of dysfunctional and autoreactive lymphocytes is defective and contributes to the pathogenesis of these disorders. Based on this hypothesis, it would not be surprising to find an increased incidence of autoimmune manifestations that are associated with these disorders. Autoimmune paraneoplastic syndromes (PNS) are often the result of a dysfunctional immune response, which is related to an underlying malignant process. While all the PNS that are associated with lymphoproliferative disorders do not have an autoimmune basis, many do. Here we review the literature of PNS associated with lymphoproliferative disorders. A concise overview of each syndrome is provided with a focus on clinical manifestations, diagnostics, pathophysiology, and treatment. While the treatment is typically directed at managing the underlying lymphoproliferative process, and can be assumed to be case throughout this review, there are exceptions that are described within the context of each disorder.

KW - Autoimmune

KW - Lymphoproliferative disorders

KW - Paraneoplastic

UR - http://www.scopus.com/inward/record.url?scp=77649237304&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77649237304&partnerID=8YFLogxK

U2 - 10.1016/j.autrev.2009.11.009

DO - 10.1016/j.autrev.2009.11.009

M3 - Article

C2 - 19914405

AN - SCOPUS:77649237304

VL - 9

JO - Autoimmunity Reviews

JF - Autoimmunity Reviews

SN - 1568-9972

IS - 5

ER -