Abstract
Ten healthy adult mares were given a single intramuscular dose (2.2 mg/kg) of gentamicin sulfate. Over a 48-h period, gentamicin concentrations were measured serially in the serum of all ten mares and in synovial fluid, peritoneal fluid, and urine of six of the mares. The mean peak serum gentamicin concentration was 5.73 micrograms/ml at 1 h. Gentamicin was detected in synovial fluid and peritoneal fluid, with mean peak gentamicin concentrations of 2.41 micrograms/ml and 3.92 micrograms/ml, respectively, observed at 2 h. These concentrations declined in parallel with serum concentrations and were not measurable at 48 h. Urine gentamicin concentration was relatively high, with a mean peak concentration of 424.9 micrograms/ml at 1 h after drug administration.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 119-122 |
| Number of pages | 4 |
| Journal | Journal of Veterinary Pharmacology and Therapeutics |
| Volume | 5 |
| Issue number | 2 |
| State | Published - Jun 1982 |
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ASJC Scopus subject areas
- Pharmacology
- veterinary(all)
Cite this
Gentamicin sulfate in the horse : serum, synovial, peritoneal, and urine concentrations after single dose intramuscular administration. / Brown, M. P.; Stover, Susan M; Kelly, R. H.; Farver, Thomas B.
In: Journal of Veterinary Pharmacology and Therapeutics, Vol. 5, No. 2, 06.1982, p. 119-122.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Gentamicin sulfate in the horse
T2 - serum, synovial, peritoneal, and urine concentrations after single dose intramuscular administration.
AU - Brown, M. P.
AU - Stover, Susan M
AU - Kelly, R. H.
AU - Farver, Thomas B
PY - 1982/6
Y1 - 1982/6
N2 - Ten healthy adult mares were given a single intramuscular dose (2.2 mg/kg) of gentamicin sulfate. Over a 48-h period, gentamicin concentrations were measured serially in the serum of all ten mares and in synovial fluid, peritoneal fluid, and urine of six of the mares. The mean peak serum gentamicin concentration was 5.73 micrograms/ml at 1 h. Gentamicin was detected in synovial fluid and peritoneal fluid, with mean peak gentamicin concentrations of 2.41 micrograms/ml and 3.92 micrograms/ml, respectively, observed at 2 h. These concentrations declined in parallel with serum concentrations and were not measurable at 48 h. Urine gentamicin concentration was relatively high, with a mean peak concentration of 424.9 micrograms/ml at 1 h after drug administration.
AB - Ten healthy adult mares were given a single intramuscular dose (2.2 mg/kg) of gentamicin sulfate. Over a 48-h period, gentamicin concentrations were measured serially in the serum of all ten mares and in synovial fluid, peritoneal fluid, and urine of six of the mares. The mean peak serum gentamicin concentration was 5.73 micrograms/ml at 1 h. Gentamicin was detected in synovial fluid and peritoneal fluid, with mean peak gentamicin concentrations of 2.41 micrograms/ml and 3.92 micrograms/ml, respectively, observed at 2 h. These concentrations declined in parallel with serum concentrations and were not measurable at 48 h. Urine gentamicin concentration was relatively high, with a mean peak concentration of 424.9 micrograms/ml at 1 h after drug administration.
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UR - http://www.scopus.com/inward/citedby.url?scp=0020147283&partnerID=8YFLogxK
M3 - Article
C2 - 7109023
AN - SCOPUS:0020147283
VL - 5
SP - 119
EP - 122
JO - Journal of Veterinary Pharmacology and Therapeutics
JF - Journal of Veterinary Pharmacology and Therapeutics
SN - 0140-7783
IS - 2
ER -