Gentamicin sulfate in the horse: serum, synovial, peritoneal, and urine concentrations after single dose intramuscular administration.

M. P. Brown, Susan M Stover, R. H. Kelly, Thomas B Farver

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8 Citations (Scopus)

Abstract

Ten healthy adult mares were given a single intramuscular dose (2.2 mg/kg) of gentamicin sulfate. Over a 48-h period, gentamicin concentrations were measured serially in the serum of all ten mares and in synovial fluid, peritoneal fluid, and urine of six of the mares. The mean peak serum gentamicin concentration was 5.73 micrograms/ml at 1 h. Gentamicin was detected in synovial fluid and peritoneal fluid, with mean peak gentamicin concentrations of 2.41 micrograms/ml and 3.92 micrograms/ml, respectively, observed at 2 h. These concentrations declined in parallel with serum concentrations and were not measurable at 48 h. Urine gentamicin concentration was relatively high, with a mean peak concentration of 424.9 micrograms/ml at 1 h after drug administration.

Original languageEnglish (US)
Pages (from-to)119-122
Number of pages4
JournalJournal of Veterinary Pharmacology and Therapeutics
Volume5
Issue number2
StatePublished - Jun 1982

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gentamicin
intramuscular injection
Gentamicins
Horses
sulfates
urine
Urine
horses
dosage
Serum
mares
synovial fluid
Ascitic Fluid
Synovial Fluid
drugs
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmacology
  • veterinary(all)

Cite this

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abstract = "Ten healthy adult mares were given a single intramuscular dose (2.2 mg/kg) of gentamicin sulfate. Over a 48-h period, gentamicin concentrations were measured serially in the serum of all ten mares and in synovial fluid, peritoneal fluid, and urine of six of the mares. The mean peak serum gentamicin concentration was 5.73 micrograms/ml at 1 h. Gentamicin was detected in synovial fluid and peritoneal fluid, with mean peak gentamicin concentrations of 2.41 micrograms/ml and 3.92 micrograms/ml, respectively, observed at 2 h. These concentrations declined in parallel with serum concentrations and were not measurable at 48 h. Urine gentamicin concentration was relatively high, with a mean peak concentration of 424.9 micrograms/ml at 1 h after drug administration.",
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T2 - serum, synovial, peritoneal, and urine concentrations after single dose intramuscular administration.

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AU - Stover, Susan M

AU - Kelly, R. H.

AU - Farver, Thomas B

PY - 1982/6

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AB - Ten healthy adult mares were given a single intramuscular dose (2.2 mg/kg) of gentamicin sulfate. Over a 48-h period, gentamicin concentrations were measured serially in the serum of all ten mares and in synovial fluid, peritoneal fluid, and urine of six of the mares. The mean peak serum gentamicin concentration was 5.73 micrograms/ml at 1 h. Gentamicin was detected in synovial fluid and peritoneal fluid, with mean peak gentamicin concentrations of 2.41 micrograms/ml and 3.92 micrograms/ml, respectively, observed at 2 h. These concentrations declined in parallel with serum concentrations and were not measurable at 48 h. Urine gentamicin concentration was relatively high, with a mean peak concentration of 424.9 micrograms/ml at 1 h after drug administration.

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