Abstract
Helicobacter pylori BabA is the ABO blood group antigen binding adhesin, which has a closely related paralogue (BabB) whose function is unknown. PCR and DNA sequence analysis showed extensive genotypic diversity in babA and babB across different strains, as well as within a strain colonizing an individual patient. We hypothesize that diverse profiles of babA and babB reflect selective pressures for adhesion, which may differ across different hosts and within an individual over time.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4375-4378 |
| Number of pages | 4 |
| Journal | Infection and Immunity |
| Volume | 74 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 2006 |
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ASJC Scopus subject areas
- Immunology
Cite this
Genotypic profile of the outer membrane proteins BabA and BabB in clinical isolates of Helicobacter pylori. / Colbeck, Jeffrey C.; Hansen, Lori M.; Fong, Julie M.; Solnick, Jay V.
In: Infection and Immunity, Vol. 74, No. 7, 07.2006, p. 4375-4378.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Genotypic profile of the outer membrane proteins BabA and BabB in clinical isolates of Helicobacter pylori
AU - Colbeck, Jeffrey C.
AU - Hansen, Lori M.
AU - Fong, Julie M.
AU - Solnick, Jay V
PY - 2006/7
Y1 - 2006/7
N2 - Helicobacter pylori BabA is the ABO blood group antigen binding adhesin, which has a closely related paralogue (BabB) whose function is unknown. PCR and DNA sequence analysis showed extensive genotypic diversity in babA and babB across different strains, as well as within a strain colonizing an individual patient. We hypothesize that diverse profiles of babA and babB reflect selective pressures for adhesion, which may differ across different hosts and within an individual over time.
AB - Helicobacter pylori BabA is the ABO blood group antigen binding adhesin, which has a closely related paralogue (BabB) whose function is unknown. PCR and DNA sequence analysis showed extensive genotypic diversity in babA and babB across different strains, as well as within a strain colonizing an individual patient. We hypothesize that diverse profiles of babA and babB reflect selective pressures for adhesion, which may differ across different hosts and within an individual over time.
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UR - http://www.scopus.com/inward/citedby.url?scp=33745631515&partnerID=8YFLogxK
U2 - 10.1128/IAI.00485-06
DO - 10.1128/IAI.00485-06
M3 - Article
C2 - 16790815
AN - SCOPUS:33745631515
VL - 74
SP - 4375
EP - 4378
JO - Infection and Immunity
JF - Infection and Immunity
SN - 0019-9567
IS - 7
ER -