Genotypic profile of the outer membrane proteins BabA and BabB in clinical isolates of Helicobacter pylori

Jeffrey C. Colbeck; Lori M. Hansen; Julie M. Fong; Jay V Solnick

doi:10.1128/IAI.00485-06

Genotypic profile of the outer membrane proteins BabA and BabB in clinical isolates of Helicobacter pylori

Jeffrey C. Colbeck, Lori M. Hansen, Julie M. Fong, Jay V Solnick

Infectious Diseases

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Abstract

Helicobacter pylori BabA is the ABO blood group antigen binding adhesin, which has a closely related paralogue (BabB) whose function is unknown. PCR and DNA sequence analysis showed extensive genotypic diversity in babA and babB across different strains, as well as within a strain colonizing an individual patient. We hypothesize that diverse profiles of babA and babB reflect selective pressures for adhesion, which may differ across different hosts and within an individual over time.

Original language	English (US)
Pages (from-to)	4375-4378
Number of pages	4
Journal	Infection and Immunity
Volume	74
Issue number	7
DOIs	https://doi.org/10.1128/IAI.00485-06
State	Published - Jul 2006

ASJC Scopus subject areas

Immunology

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abstract = "Helicobacter pylori BabA is the ABO blood group antigen binding adhesin, which has a closely related paralogue (BabB) whose function is unknown. PCR and DNA sequence analysis showed extensive genotypic diversity in babA and babB across different strains, as well as within a strain colonizing an individual patient. We hypothesize that diverse profiles of babA and babB reflect selective pressures for adhesion, which may differ across different hosts and within an individual over time.",

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Genotypic profile of the outer membrane proteins BabA and BabB in clinical isolates of Helicobacter pylori

Abstract

ASJC Scopus subject areas

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