Genotypic profile of the outer membrane proteins BabA and BabB in clinical isolates of Helicobacter pylori

Jeffrey C. Colbeck, Lori M. Hansen, Julie M. Fong, Jay V Solnick

Research output: Contribution to journalArticle

58 Scopus citations

Abstract

Helicobacter pylori BabA is the ABO blood group antigen binding adhesin, which has a closely related paralogue (BabB) whose function is unknown. PCR and DNA sequence analysis showed extensive genotypic diversity in babA and babB across different strains, as well as within a strain colonizing an individual patient. We hypothesize that diverse profiles of babA and babB reflect selective pressures for adhesion, which may differ across different hosts and within an individual over time.

Original languageEnglish (US)
Pages (from-to)4375-4378
Number of pages4
JournalInfection and Immunity
Volume74
Issue number7
DOIs
StatePublished - Jul 2006

ASJC Scopus subject areas

  • Immunology

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