Genomics of Brain Aging: Nuclear and Mitochondrial Genomes

A. Prigione, Gino A Cortopassi, C. Ferrarese

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In recent times, the study of genomic changes associated with age has been improved by the introduction of microarray technology, which allows the detection of whole-genome expression profiles using single samples. Nuclear transcriptional modifications associated with the physiology and pathology of brain aging indicate the involvement of multiple relevant pathways. Several of these pathways are shared by cells bearing mitochondrial DNA mutations, which are known to increase with age. Taken together, these studies may help to define the role of mitochondria in the process of aging and eventually to identify a genomic fingerprint of brain aging.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd
Pages695-701
Number of pages7
ISBN (Print)9780080450469
DOIs
StatePublished - 2010

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Keywords

  • Apoptosis
  • Brain aging
  • Calcium dysfunction
  • Caloric restriction
  • Microarray
  • Mitochondrial deletions
  • Mitochondrial mutations
  • Neurodegeneration
  • Oxidative stress
  • Transcriptional profile

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Prigione, A., Cortopassi, G. A., & Ferrarese, C. (2010). Genomics of Brain Aging: Nuclear and Mitochondrial Genomes. In Encyclopedia of Neuroscience (pp. 695-701). Elsevier Ltd. https://doi.org/10.1016/B978-008045046-9.00134-0