Genomic views of transcriptional enhancers: Essential determinants of cellular identity and activity-dependent responses in the CNS

Jesse M. Gray, Tae Kyung Kim, Anne E. West, Alexander Nord, Eirene Markenscoff-Papadimitriou, Stavros Lomvardas

Research output: Contribution to journalReview article

20 Scopus citations

Abstract

Sprinkled throughout the genome are a million regulatory sequences called transcriptional enhancers that activate gene promoters in the right cells, at the right time. Enhancers endow the brain with its incredible diversity of cell types and also translate neural activity into gene induction. Thanks to rapid advances in genomic technologies, it is now possible to identify thousands of enhancers rapidly, test their transcriptional function en masse, and address their neurobiological functions via genome editing. Enhancers also promise to be a great technological opportunity for neuroscience, offering the potential for cell-type-specific genetic labeling and manipulation without the need for transgenesis. The objective of this review and the accompanying 2015 SfN mini-symposium is to highlight the use of new and emerging genomic technologies to probe enhancer function in the nervous system.

Original languageEnglish (US)
Pages (from-to)13819-13826
Number of pages8
JournalJournal of Neuroscience
Volume35
Issue number41
DOIs
StatePublished - Oct 14 2015

ASJC Scopus subject areas

  • Neuroscience(all)

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